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ICAM2 intercellular adhesion molecule 2 [ Homo sapiens (human) ]

Gene ID: 3384, updated on 2-Nov-2024

Summary

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Official Symbol
ICAM2provided by HGNC
Official Full Name
intercellular adhesion molecule 2provided by HGNC
Primary source
HGNC:HGNC:5345
See related
Ensembl:ENSG00000108622 MIM:146630; AllianceGenome:HGNC:5345
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD102
Summary
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 62.3), placenta (RPKM 26.4) and 17 other tissues See more
Orthologs
mouse all
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Genomic context

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See ICAM2 in Genome Data Viewer
Location:
17q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (64002595..64020633, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (64873371..64891380, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62079955..62097993, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:62037321-62038319 Neighboring gene uncharacterized LOC105371858 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:62044651-62044849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62045661-62046161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62064225-62064778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62064779-62065330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62075897-62076874 Neighboring gene PRR29 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62083286-62083980 Neighboring gene proline rich 29 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12571 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:62097827-62098327 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12573 Neighboring gene CRISPRi-validated cis-regulatory element chr17.4314 Neighboring gene CRISPRi-validated cis-regulatory element chr17.4315 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:62132617-62133360 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:62133361-62134104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8837 Neighboring gene endoplasmic reticulum to nucleus signaling 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12578 Neighboring gene Sharpr-MPRA regulatory region 10488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8839 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12585 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12586 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:62223017-62223571 Neighboring gene small nucleolar RNA, C/D box 104 Neighboring gene small nucleolar RNA host gene 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1. de Fougerolles AR, et al. J Exp Med, 1991 Jul 1. PMID 1676048, Free PMC Article
  2. Differential expression of cytokines (IL-2, IFN-gamma, IL-10) and adhesion molecules (VCAM-1, LFA-1, CD44) between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis. Yang J, et al. Scand J Immunol, 2002 Sep. PMID 12193230
  3. Recruitment of lymphocytes to the human liver. Lalor PF, et al. Immunol Cell Biol, 2002 Feb. PMID 11869363
  4. N-glycosylation of ICAM-2 is required for ICAM-2-mediated complete suppression of metastatic potential of SK-N-AS neuroblastoma cells. Feduska JM, et al. BMC Cancer, 2013 May 28. PMID 23714211, Free PMC Article
  5. Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily. Casasnovas JM, et al. Proc Natl Acad Sci U S A, 1999 Mar 16. PMID 10077629, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis.
    Title: Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis.
  2. ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the Airways In Vivo.
    Title: ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the Airways In Vivo.
  3. Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions.
    Title: Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions.
  4. ICAM2 induction by p53 has a key role in inhibiting cancer cell migration and invasion.ICAM2 acts at least in part through the suppression of the MEK-ERK signaling pathway.
    Title: Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 target.
  5. INDEED also identified some candidates previously reported to be relevant to HCC, such as intercellular adhesion molecule 2 (ICAM2) and c4b-binding protein alpha chain (C4BPA), which were missed by both Differential expression and differential network analyses
    Title: INDEED: Integrated differential expression and differential network analysis of omic data for biomarker discovery.
  6. Both ICAM-2 and ICAM-1 levels in plasma were markedly increased in Ankylosing Spondylitis Chinese patients compared to controls.
    Title: Association Between Intercellular Adhesion Molecule-1, -2, -3 Plasma Levels and Disease Activity of Ankylosing Spondylitis in the Chinese Han Population.
  7. Soluble ICAM2 was higher in ADHD patients than in controls.
    Title: Relationship between soluble intercellular adhesion molecules and attention-deficit/hyperactivity disorder.
  8. ICAM-1 and ICAM-2 are involved in each step of neutrophil extravasation, and have redundant but also distinct functions. Analysis of the role of endothelial ICAM-1 requires simultaneous consideration of ICAM-2.
    Title: The physiological roles of ICAM-1 and ICAM-2 in neutrophil migration into tissues.
  9. Results indicate that the interaction of ICAM-2 with alpha-actinin is critical to conferring an ICAM-2-mediated non-metastatic phenotype in neuroblastoma cells.
    Title: ICAM-2 confers a non-metastatic phenotype in neuroblastoma cells by interaction with α-actinin.
  10. with larger patient groups and preferably detailed histopathological and clinical evaluations, are needed to explain the severity of ICAM-1, ICAM-2, and ICAM-3 molecules in Barrett's esophagus
    Title: Investigation of intercellular adhesion molecules (ICAMs) gene expressions in patients with Barrett's esophagus.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ICAM2 PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of intercellular adhesion molecule 2 (ICAM2, CD102) PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of intercellular adhesion molecule 2 (ICAM2, CD102) PubMed
vpu HIV-1 Vpu is identified to have a physical interaction with intercellular adhesion molecule 2 (ICAM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in microvillus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in uropod IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
intercellular adhesion molecule 2
Names
ICAM-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000873.4 → NP_000864.2  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_000864.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598, Q14600
    UniProtKB/TrEMBL
    A8KAP5, Q6FHE2
    Related
    ENSP00000392634.2, ENST00000449662.6
    Conserved Domains (2) summary
    cd05755
    Location:112 → 211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24 → 109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

  2. NM_001099786.2 → NP_001093256.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001093256.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, BX363874, CA841927
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598, Q14600
    UniProtKB/TrEMBL
    A8KAP5, Q6FHE2
    Related
    ENSP00000415283.1, ENST00000412356.5
    Conserved Domains (2) summary
    cd05755
    Location:112 → 211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24 → 109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

  3. NM_001099787.2 → NP_001093257.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001093257.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, BX363874, CA841927
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598, Q14600
    UniProtKB/TrEMBL
    A8KAP5, Q6FHE2
    Related
    ENSP00000388666.1, ENST00000418105.5
    Conserved Domains (2) summary
    cd05755
    Location:112 → 211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24 → 109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

  4. NM_001099788.2 → NP_001093258.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001093258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, CA841927
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598, Q14600
    UniProtKB/TrEMBL
    A8KAP5, Q6FHE2
    Related
    ENSP00000462579.1, ENST00000579687.5
    Conserved Domains (2) summary
    cd05755
    Location:112 → 211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24 → 109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

  5. NM_001099789.2 → NP_001093259.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001093259.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, CA841927
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598, Q14600
    UniProtKB/TrEMBL
    A8KAP5, Q6FHE2
    Related
    ENSP00000464665.1, ENST00000579788.6
    Conserved Domains (2) summary
    cd05755
    Location:112 → 211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24 → 109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    64002595..64020633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    64873371..64891380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13598.2 GenPept UniProtKB/Swiss-Prot:P13598

Gene LinkOut

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