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Tmem220 transmembrane protein 220 [ Mus musculus (house mouse) ]

Gene ID: 338369, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem220provided by MGI
Official Full Name
transmembrane protein 220provided by MGI
Primary source
MGI:MGI:2443691
See related
Ensembl:ENSMUSG00000050270 AllianceGenome:MGI:2443691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be located in membrane. Orthologous to human TMEM220 (transmembrane protein 220). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver adult (RPKM 4.1), liver E18 (RPKM 3.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem220 in Genome Data Viewer
Location:
11 B3; 11 40.59 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (66915959..66927818)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67025154..67035312)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 238 like Neighboring gene STARR-positive B cell enhancer ABC_E8414 Neighboring gene STARR-seq mESC enhancer starr_29788 Neighboring gene predicted gene 12299 Neighboring gene STARR-seq mESC enhancer starr_29789 Neighboring gene STARR-seq mESC enhancer starr_29791 Neighboring gene ADP-ribose/CDP-alcohol diphosphatase, manganese dependent Neighboring gene STARR-seq mESC enhancer starr_29794 Neighboring gene SCO1 cytochrome c oxidase assembly protein Neighboring gene myosin, heavy polypeptide 3, skeletal muscle, embryonic Neighboring gene microRNA 6923

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC130169, MGC130170, A730055C05Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 220

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291042.1 → NP_001277971.1  transmembrane protein 220 isoform 2

    See identical proteins and their annotated locations for NP_001277971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK043094, AK078505
    Consensus CDS
    CCDS70209.1
    UniProtKB/Swiss-Prot
    Q2TB06, Q8BP07, Q8C936
    Related
    ENSMUSP00000057366.6, ENSMUST00000061786.6
    Conserved Domains (1) summary
    pfam15071
    Location:29 → 118
    TMEM220; Transmembrane family 220, helix

  2. NM_001291043.1 → NP_001277972.1  transmembrane protein 220 isoform 3

    See identical proteins and their annotated locations for NP_001277972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK078505, BC110629
    UniProtKB/Swiss-Prot
    Q8BP07
    Conserved Domains (1) summary
    pfam15071
    Location:29 → 102
    TMEM220; Transmembrane family 220, helix

  3. NM_177392.3 → NP_796366.1  transmembrane protein 220 isoform 1

    See identical proteins and their annotated locations for NP_796366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK043094, AK078505
    Consensus CDS
    CCDS24850.1
    UniProtKB/Swiss-Prot
    Q8BP07
    Related
    ENSMUSP00000078084.6, ENSMUST00000079077.12
    Conserved Domains (1) summary
    pfam15071
    Location:29 → 142
    TMEM220; Transmembrane family 220, helix

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    66915959..66927818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156786.1 → XP_036012679.1  transmembrane protein 220 isoform X1

    Conserved Domains (1) summary
    pfam15071
    Location:32 → 108
    TMEM220; Transmembrane family 220, helix
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BP07.1 GenPept UniProtKB/Swiss-Prot:Q8BP07

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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