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Pheta2 PH domain containing endocytic trafficking adaptor 2 [ Mus musculus (house mouse) ]

Gene ID: 338368, updated on 18-Sep-2024

Summary

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Official Symbol
Pheta2provided by MGI
Official Full Name
PH domain containing endocytic trafficking adaptor 2provided by MGI
Primary source
MGI:MGI:2443609
See related
Ensembl:ENSMUSG00000049687 AllianceGenome:MGI:2443609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ses2; Fam109b; IPIP27B; C920005C14Rik
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in endosome organization; receptor recycling; and retrograde transport, endosome to Golgi. Predicted to be located in clathrin-coated vesicle. Predicted to be active in early endosome; recycling endosome; and trans-Golgi network. Orthologous to human PHETA2 (PH domain containing endocytic trafficking adaptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 14.4), liver E14 (RPKM 13.8) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Pheta2 in Genome Data Viewer
Location:
15 E1; 15 38.56 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82223148..82229911)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82338927..82345710)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene WBP2 N-terminal like Neighboring gene N-acetyl galactosaminidase, alpha Neighboring gene STARR-seq mESC enhancer starr_39293 Neighboring gene nuclear encoded rRNA 5S 41 Neighboring gene single-pass membrane protein with aspartate rich tail 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82192158-82192359 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1. Swan LE, et al. Proc Natl Acad Sci U S A, 2010 Feb 23. PMID 20133602, Free PMC Article
  2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sesquipedalian-2
Names
27 kDa inositol polyphosphate phosphatase interacting protein B
family with sequence similarity 109, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357717.1 → NP_001344646.1  sesquipedalian-2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC104325
    Consensus CDS
    CCDS27687.1
    UniProtKB/Swiss-Prot
    Q14B98, Q8BUL8
    UniProtKB/TrEMBL
    A0A0R4J1Z2
    Related
    ENSMUSP00000124703.2, ENSMUST00000161178.2
    Conserved Domains (1) summary
    cl17171
    Location:11 → 138
    PH-like; Pleckstrin homology-like domain

  2. NM_177391.4 → NP_796365.1  sesquipedalian-2

    See identical proteins and their annotated locations for NP_796365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK083325, BY775160, CJ162278
    Consensus CDS
    CCDS27687.1
    UniProtKB/Swiss-Prot
    Q14B98, Q8BUL8
    UniProtKB/TrEMBL
    A0A0R4J1Z2
    Related
    ENSMUSP00000060598.3, ENSMUST00000050349.3
    Conserved Domains (1) summary
    cl17171
    Location:11 → 138
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82223148..82229911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245682.3 → XP_011243984.1  sesquipedalian-2 isoform X1

    See identical proteins and their annotated locations for XP_011243984.1

    UniProtKB/Swiss-Prot
    Q14B98, Q8BUL8
    UniProtKB/TrEMBL
    A0A0R4J1Z2
    Conserved Domains (1) summary
    cl17171
    Location:11 → 138
    PH-like; Pleckstrin homology-like domain

  2. XM_011245681.4 → XP_011243983.1  sesquipedalian-2 isoform X1

    See identical proteins and their annotated locations for XP_011243983.1

    UniProtKB/Swiss-Prot
    Q14B98, Q8BUL8
    UniProtKB/TrEMBL
    A0A0R4J1Z2
    Conserved Domains (1) summary
    cl17171
    Location:11 → 138
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14B98.1 GenPept UniProtKB/Swiss-Prot:Q14B98

Gene LinkOut

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