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CEBPB CCAAT enhancer binding protein beta [ Bos taurus (domestic cattle) ]

Gene ID: 338319, updated on 4-Oct-2024

Summary

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Gene symbol
CEBPB
Gene description
CCAAT enhancer binding protein beta
See related
Ensembl:ENSBTAG00000051972
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See CEBPB in Genome Data Viewer
Location:
chromosome: 13
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (78205757..78206803)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 V1 Neighboring gene plasmanylethanolamine desaturase 1 Neighboring gene uncharacterized LOC100847835 Neighboring gene uncharacterized LOC132346985

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of C/EBPβ Affects The Cell Cycle Regulators and Spermatogenesis Related Genes Expression And Function of Bovine Sertoli Cells. Tang K, et al. Reprod Domest Anim, 2016 Aug. PMID 27333951
  2. Rapid communication: nucleotide sequence of bovine C/EBP beta gene. Yamaoka I, et al. J Anim Sci, 1997 Feb. PMID 9051485
  3. Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha gene in cattle. Shi X, et al. BMC Mol Biol, 2012 Jun 27. PMID 22738246, Free PMC Article
  4. Dual effect of a single nucleotide polymorphism in the first intron of the porcine secreted phosphoprotein 1 gene: allele-specific binding of C/EBP beta and activation of aberrant splicing. Muráni E, et al. BMC Mol Biol, 2009 Oct 21. PMID 19845957, Free PMC Article
  5. Stearoyl-CoA desaturase 1 expression is downregulated in liver and udder during E. coli mastitis through enhanced expression of repressive C/EBP factors and reduced expression of the inducer SREBP1A. Xu T, et al. BMC Mol Biol, 2016 Jul 20. PMID 27439381, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SREBP1a activated while C/EBP factors downregulated the activity of the SCD1 promoter.
    Title: Stearoyl-CoA desaturase 1 expression is downregulated in liver and udder during E. coli mastitis through enhanced expression of repressive C/EBP factors and reduced expression of the inducer SREBP1A.
  2. These results indicate that the C/EBPbeta gene plays an important regulatory role in regulation of the cell cycle regulators and spermatogenesis-related genes expression and function of bovine SCs.
    Title: Overexpression of C/EBPβ Affects The Cell Cycle Regulators and Spermatogenesis Related Genes Expression And Function of Bovine Sertoli Cells.
  3. Suppression of CPT1B and induction of SCD and CEBPB by supplemental arginine promotes increased adiposity in Angus steers.
    Title: Abomasal infusion of arginine stimulates SCD and C/EBPß gene expression, and decreases CPT1ß gene expression in bovine adipose tissue independent of conjugated linoleic acid.
  4. Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 gene expression in adipocytes.
    Title: Co-culture of bovine muscle satellite cells with preadipocytes increases PPARγ and C/EBPβ gene expression in differentiated myoblasts and increases GPR43 gene expression in adipocytes.
  5. Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha gene in cattle.
    Title: Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha gene in cattle.
  6. The role of NF-kappaB and C/EBP factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
    Title: Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-κB p65 and C/EBPβ in mammary epithelial cells.
  7. The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta binding site and this binding site is negatively affected by the mutant G allele.
    Title: Dual effect of a single nucleotide polymorphism in the first intron of the porcine secreted phosphoprotein 1 gene: allele-specific binding of C/EBP beta and activation of aberrant splicing.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
CCAAT/enhancer-binding protein beta
Names
CCAAT/enhancer binding protein (C/EBP), beta
c/EBP beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176788.1 → NP_789745.1  CCAAT/enhancer-binding protein beta

    See identical proteins and their annotated locations for NP_789745.1

    Status: PROVISIONAL

    Source sequence(s)
    D82985
    UniProtKB/Swiss-Prot
    O02755
    UniProtKB/TrEMBL
    A0A3Q1NLC4
    Related
    ENSBTAP00000095987.1, ENSBTAT00000103441.1
    Conserved Domains (1) summary
    cd14712
    Location:267 → 337
    bZIP_CEBPB; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein beta (CEBPB): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    78205757..78206803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02755.1 GenPept UniProtKB/Swiss-Prot:O02755

Gene LinkOut

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Molecular Biology Databases
Research Materials