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SQSTM1 sequestosome 1 [ Bos taurus (domestic cattle) ]

Gene ID: 338045, updated on 10-Aug-2024

Summary

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Official Symbol
SQSTM1provided by VGNC
Official Full Name
sequestosome 1provided by VGNC
Primary source
VGNC:VGNC:35265
See related
BGD:BT16900; Ensembl:ENSBTAG00000015591
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See SQSTM1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (1435469..1507800, complement)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 130 Neighboring gene uncharacterized LOC107132589 Neighboring gene TBC1 domain family member 9B Neighboring gene small integral membrane protein 15 Neighboring gene MRN complex interacting protein Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene leukotriene C4 synthase Neighboring gene mastermind like transcriptional coactivator 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response. Ying YT, et al. Cells, 2021 Dec 6. PMID 34943933, Free PMC Article
  2. Spartin recruits PKC-ζ via the PKC-ζ-interacting proteins ZIP1 and ZIP3 to lipid droplets. Urbanczyk A, et al. J Neurochem, 2011 Sep. PMID 21707618
  3. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
  4. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response.
    Title: Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC127197

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase C binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in aggrephagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endosome organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitophagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in aggresome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in amphisome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sequestosome-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176641.1 → NP_788814.1  sequestosome-1

    See identical proteins and their annotated locations for NP_788814.1

    Status: PROVISIONAL

    Source sequence(s)
    BC108087
    UniProtKB/TrEMBL
    A7E3V0, Q32PJ9
    Related
    ENSBTAP00000059264.2, ENSBTAT00000075019.2
    Conserved Domains (3) summary
    cd06402
    Location:4 → 102
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd02340
    Location:126 → 168
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    pfam16577
    Location:379 → 439
    UBA_5; UBA domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    1435469..1507800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024993877.2 → XP_024849645.1  sequestosome-1 isoform X1

    UniProtKB/TrEMBL
    A7E3V0
    Conserved Domains (3) summary
    cd02340
    Location:42 → 84
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cl02720
    Location:1 → 18
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
    pfam16577
    Location:295 → 356
    UBA_5; UBA domain

  2. XM_010806433.4 → XP_010804735.1  sequestosome-1 isoform X2

    UniProtKB/TrEMBL
    A7E3V0, F1MIE2
    Related
    ENSBTAP00000020709.6, ENSBTAT00000020709.7
    Conserved Domains (3) summary
    cd06402
    Location:4 → 102
    PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
    cd02340
    Location:126 → 168
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    pfam16577
    Location:352 → 412
    UBA_5; UBA domain
Nucleotide Protein Strain
Heading Accession and Version

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