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CASP4 caspase 4, apoptosis-related cysteine peptidase [ Bos taurus (domestic cattle) ]

Gene ID: 338039, updated on 12-Oct-2024

Summary

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Gene symbol
CASP4
Gene description
caspase 4, apoptosis-related cysteine peptidase
See related
BGD:BT22749; Ensembl:ENSBTAG00000020884
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CASP13
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Genomic context

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See CASP4 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (3250033..3269685)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene caspase 1 Neighboring gene RNA-binding protein EWS-like Neighboring gene zinc finger protein 596-like pseudogene

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence that caspase-13 is not a human but a bovine gene. Koenig U, et al. Biochem Biophys Res Commun, 2001 Aug 3. PMID 11478774
  2. ERICE, a novel FLICE-activatable caspase. Humke EW, et al. J Biol Chem, 1998 Jun 19. PMID 9624166
  3. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
  4. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC137679

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables caspase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
caspase-4
Names
CASP-13
CASP-4
ERICE
caspase 4, apoptosis-related cysteine protease
caspase-13
evolutionary related interleukin-1-beta-converting enzyme
NP_788811.1
XP_010810586.1
XP_010810587.1
XP_015330059.1
XP_059730564.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176638.5 → NP_788811.1  caspase-4

    See identical proteins and their annotated locations for NP_788811.1

    Status: PROVISIONAL

    Source sequence(s)
    BC112708
    UniProtKB/Swiss-Prot
    O75601, Q5E9C1
    UniProtKB/TrEMBL
    A0AAF6Z8F0
    Related
    ENSBTAP00000027820.4, ENSBTAT00000027820.5
    Conserved Domains (2) summary
    smart00115
    Location:126 → 375
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08325
    Location:5 → 85
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    3250033..3269685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015474573.3 → XP_015330059.1  caspase-4 isoform X1

    UniProtKB/TrEMBL
    A0AAF6Z8F0
    Conserved Domains (2) summary
    smart00115
    Location:194 → 443
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08325
    Location:73 → 153
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

  2. XM_010812285.4 → XP_010810587.1  caspase-4 isoform X3

    UniProtKB/TrEMBL
    A0AAA9SMN6, A0AAF6Z8F0
    Related
    ENSBTAP00000087618.1, ENSBTAT00000116406.1
    Conserved Domains (1) summary
    smart00115
    Location:110 → 359
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  3. XM_059874581.1 → XP_059730564.1  caspase-4 isoform X2

  4. XM_010812284.4 → XP_010810586.1  caspase-4 isoform X2

    UniProtKB/TrEMBL
    A0AAF6Z8F0
    Related
    ENSBTAP00000052549.2, ENSBTAT00000052006.4
    Conserved Domains (2) summary
    smart00115
    Location:114 → 363
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cl14633
    Location:1 → 73
    DD; Death Domain Superfamily of protein-protein interaction domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75601.1 GenPept UniProtKB/Swiss-Prot:O75601
Q5E9C1.1 GenPept UniProtKB/Swiss-Prot:Q5E9C1

Gene LinkOut

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