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yrk Yes-related kinase [ Danio rerio (zebrafish) ]

Gene ID: 337571, updated on 2-Nov-2024

Summary

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Official Symbol
yrkprovided by ZNC
Official Full Name
Yes-related kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9517
See related
Ensembl:ENSDARG00000004378 AllianceGenome:ZFIN:ZDB-GENE-030131-9517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj84d04; zgc:92165; wu:fj84d04
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within macrophage chemotaxis. Predicted to be active in plasma membrane. Is expressed in blood island; cardiovascular system; head; mesoderm; and post-vent region. Orthologous to human FGR (FGR proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See yrk in Genome Data Viewer
Location:
chromosome: 19
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (43359084..43432415)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (43797085..43836818)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene matrilin 1 Neighboring gene sestrin 2 Neighboring gene probable methyltransferase-like protein 24 Neighboring gene AT hook, DNA binding motif, containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish. Sipka T, et al. Front Immunol, 2021. PMID 33841419, Free PMC Article
  2. Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression. Gurevich DB, et al. EMBO J, 2018 Jul 2. PMID 29866703, Free PMC Article
  3. Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. Tauzin S, et al. J Cell Biol, 2014 Dec 8. PMID 25488917, Free PMC Article
  4. Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. Yoo SK, et al. J Cell Biol, 2012 Oct 15. PMID 23045550, Free PMC Article
  5. Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Yoo SK, et al. Nature, 2011 Nov 20. PMID 22101434, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC92165

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Fgr
Names
Yes-relayed kinase
NP_001352482.1
NP_997946.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365553.1 → NP_001352482.1  tyrosine-protein kinase Fgr isoform 1

    Status: VALIDATED

    Source sequence(s)
    CU104776
    Related
    ENSDARP00000121344.1, ENSDART00000148287.3
    Conserved Domains (3) summary
    cd14203
    Location:266 → 513
    PTKc_Src_Fyn_like; Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases
    cl15255
    Location:136 → 234
    SH2; Src homology 2 (SH2) domain
    cl17036
    Location:76 → 133
    SH3; Src Homology 3 domain superfamily

  2. NM_212781.2 → NP_997946.1  tyrosine-protein kinase Fgr isoform 2

    See identical proteins and their annotated locations for NP_997946.1

    Status: VALIDATED

    Source sequence(s)
    CU104776
    UniProtKB/TrEMBL
    A0A8M1PFN7, Q8AWF1
    Related
    ENSDARP00000122444.1, ENSDART00000136695.3
    Conserved Domains (4) summary
    cd10367
    Location:136 → 236
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cd14203
    Location:263 → 510
    PTKc_Src_Fyn_like; Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases
    pfam07714
    Location:259 → 508
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:76 → 133
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    43359084..43432415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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