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rars1 arginyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

Gene ID: 337070, updated on 2-Nov-2024

Summary

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Official Symbol
rars1provided by ZNC
Official Full Name
arginyl-tRNA synthetase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9014
See related
Ensembl:ENSDARG00000054530 AllianceGenome:ZFIN:ZDB-GENE-030131-9014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rars; zgc:56050; zgc:86730; wu:fa96g09
Summary
Predicted to enable arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be located in cytoplasm. Is expressed in several structures, including digestive system; immature eye; nervous system; pectoral fin bud; and swim bladder. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See rars1 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (35327374..35378321)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (35292884..35343831)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-23e4.3 Neighboring gene interleukin 12B, b Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 Neighboring gene uncharacterized LOC137488839 Neighboring gene sarcoglycan, delta (dystrophin-associated glycoprotein)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Systematic expression profiling of neuropathy-related aminoacyl-tRNA synthetases in zebrafish during development. Giong HK, et al. Biochem Biophys Res Commun, 2022 Jan 8. PMID 34872004
  2. A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases. Waldron AL, et al. PLoS One, 2017. PMID 28934368, Free PMC Article
  3. Biallelic variants in KARS1 are associated with neurodevelopmental disorders and hearing loss recapitulated by the knockout zebrafish. Lin SJ, et al. Genet Med, 2021 Oct. PMID 34172899, Free PMC Article
  4. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC86730

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables arginine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within arginyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
arginine--tRNA ligase, cytoplasmic
NP_956342.1
XP_017208243.1
XP_068071909.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200048.1 → NP_956342.1  arginine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_956342.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045884
    UniProtKB/TrEMBL
    Q7ZVF4
    Related
    ENSDARP00000107383.2, ENSDART00000130626.4
    Conserved Domains (5) summary
    cd00671
    Location:194 → 458
    ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
    smart01016
    Location:79 → 167
    Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal dom
    PLN02286
    Location:79 → 661
    PLN02286; arginine-tRNA ligase
    cl12020
    Location:497 → 661
    Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains
    cl19252
    Location:5 → 58
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    35327374..35378321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215808.1 → XP_068071909.1  arginine--tRNA ligase, cytoplasmic isoform X1

  2. XM_017352754.3 → XP_017208243.1  arginine--tRNA ligase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z3L7

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395096.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    307711..339966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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