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Mon1 Monensin sensitivity 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33689, updated on 28-Oct-2024

Summary

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Official Symbol
Mon1provided by FlyBase
Official Full Name
Monensin sensitivity 1provided by FlyBase
Primary source
FLYBASE:FBgn0031640
Locus tag
Dmel_CG11926
See related
AllianceGenome:FB:FBgn0031640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11926; Dmel\CG11926; dMon1; Dmon1; mon1; MON1; NP_608868
Summary
Enables guanyl nucleotide exchange factor inhibitor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in endosome to lysosome transport via multivesicular body sorting pathway and neuromuscular junction development. Located in cytosol and synaptic cleft. Part of Mon1-Ccz1 complex. Is expressed in adult head. Orthologous to several human genes including MON1A (MON1 homolog A, secretory trafficking associated). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See Mon1 in Genome Data Viewer
Location:
25B1-25B1; 2-14 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4850641..4852640)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4850641..4852640)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mextli Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S2 Neighboring gene smog Neighboring gene Chorion factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation. Yong X, et al. Proc Natl Acad Sci U S A, 2023 May 30. PMID 37216550, Free PMC Article
  2. Drosophila Mon1 and Rab7 interact to regulate glutamate receptor levels at the neuromuscular junction. Basargekar A, et al. Int J Dev Biol, 2020. PMID 32658990
  3. Rab26 controls secretory granule maturation and breakdown in Drosophila. Boda A, et al. Cell Mol Life Sci, 2023 Jan 4. PMID 36600084, Free PMC Article
  4. A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function. Dehnen L, et al. J Cell Sci, 2020 Jul 9. PMID 32499409
  5. Monensin Sensitive 1 Regulates Dendritic Arborization in Drosophila by Modulating Endocytic Flux. Harish RK, et al. Front Cell Dev Biol, 2019. PMID 31428611, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila Mon1 and Rab7 interact to regulate glutamate receptor levels at the neuromuscular junction.
    Title: Drosophila Mon1 and Rab7 interact to regulate glutamate receptor levels at the neuromuscular junction.
  2. Mon1 is a novel molecular player in the brain-gonad axis; this underscores the significance of inter-organ systemic communication during development.
    Title: Drosophila Mon1 constitutes a novel node in the brain-gonad axis that is essential for female germline maturation.
  3. We propose that DMon1 is part of a presynaptically regulated transsynaptic mechanism that regulates GluRIIA levels at the larval neuromuscular junction.
    Title: A Presynaptic Regulatory System Acts Transsynaptically via Mon1 to Regulate Glutamate Receptor Levels in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl nucleotide exchange factor inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endosome to lysosome transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome to lysosome transport via multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Mon1-Ccz1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Mon1-Ccz1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Mon1-Ccz1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic cleft IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
monensin sensitivity 1
Names
CG11926-PA
Mon1 ortholog
Mon1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    4850641..4852640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135024.2 → NP_608868.1  monensin sensitivity 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608868.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VR38
    UniProtKB/TrEMBL
    Q8MRZ0
    Related
    FBpp0077079
    Conserved Domains (1) summary
    pfam03164
    Location:115 → 527
    Mon1; Trafficking protein Mon1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRZ0 Q8MRZ0
Q9VR38 Q9VR38
Q9VR38.1

Gene LinkOut

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