gna13b guanine nucleotide binding protein (G protein), alpha 13b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gna13bprovided by ZNC
Official Full Name: guanine nucleotide binding protein (G protein), alpha 13bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8277
See related: Ensembl:ENSDARG00000037924 AllianceGenome:ZFIN:ZDB-GENE-030131-8277
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Gna13; fj64c01; wu:fj64c01
Summary: Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Acts upstream of or within several processes, including circulatory system development; gastrulation; and glial cell development. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in brush border membrane and cytoplasm. Is expressed in gill; head; intermediate cell mass of mesoderm; nervous system; and trunk. Orthologous to human GNA13 (G protein subunit alpha 13). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (36332579..36364903, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (36202981..36235305, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In embryos defective for S1pr2/Galpha13 signaling, endocardial precursors failed to migrate towards the midline, and the presumptive endocardium surrounded the bilaterally-located myocardial cells rather than being encompassed by them.
Title: S1pr2/Gα13 signaling regulates the migration of endocardial precursors by controlling endoderm convergence.
S1pr2/Galpha13 signaling controls myocardial migration by regulating endoderm convergence.
Title: S1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables D5 dopamine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell migration involved in heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endocardial progenitor cell migration to the midline involved in heart field formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoderm development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gastrulation with mouth forming second	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myelination of posterior lateral line nerve axons	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within oligodendrocyte development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within unidimensional cell growth	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in brush border membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanine nucleotide-binding protein subunit alpha-13b

Names: G-protein alpha 13b; Galpha 13b; guanine nucleotide binding protein, alpha 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013263.2 → NP_001013281.2 guanine nucleotide-binding protein subunit alpha-13b

See identical proteins and their annotated locations for NP_001013281.2

Status: PROVISIONAL

Source sequence(s)

BC134004

UniProtKB/TrEMBL

A4FVJ5

Related

ENSDARP00000036006.6, ENSDART00000028883.7

Conserved Domains (2) summary

cd00066
Location:49 → 371

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

smart00275
Location:29 → 375

G_alpha; G protein alpha subunit