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cdr2l cerebellar degeneration-related protein 2-like [ Danio rerio (zebrafish) ]

Gene ID: 336227, updated on 2-Nov-2024

Summary

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Official Symbol
cdr2lprovided by ZNC
Official Full Name
cerebellar degeneration-related protein 2-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8171
See related
Ensembl:ENSDARG00000026834 AllianceGenome:ZFIN:ZDB-GENE-030131-8171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj58a11; zgc:77462; wu:fj58a11
Summary
Is expressed in several structures, including nervous system; neural plate; otic vesicle; presumptive diencephalon; and presumptive telencephalon. Orthologous to human CDR2L (cerebellar degeneration related protein 2 like). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See cdr2l in Genome Data Viewer
Location:
chromosome: 3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (59951006..59981496, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (59659905..59690377, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor Neighboring gene Rho GDP dissociation inhibitor (GDI) alpha Neighboring gene uncharacterized LOC137490783 Neighboring gene si:ch211-110e21.3 Neighboring gene RecQ helicase-like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish. Ezhkova D, et al. Biol Open, 2023 Jun 15. PMID 37272628, Free PMC Article
  2. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
cerebellar degeneration-related protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316894.1 → NP_001303823.1  cerebellar degeneration-related protein 2-like

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC065979, CR352225
    UniProtKB/Swiss-Prot
    Q6NZT2
    UniProtKB/TrEMBL
    A0A8M9P4Y6
    Related
    ENSDARP00000106075.1, ENSDART00000124038.3
    Conserved Domains (1) summary
    cl25732
    Location:13 → 279
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_205564.2 → NP_991127.2  cerebellar degeneration-related protein 2-like

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC065979, CR352225
    UniProtKB/Swiss-Prot
    Q6NZT2
    UniProtKB/TrEMBL
    A0A8M9P4Y6
    Related
    ENSDARP00000035047.6, ENSDART00000035878.7
    Conserved Domains (1) summary
    cl25732
    Location:13 → 279
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    59951006..59981496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469708.2 → XP_021325383.1  cerebellar degeneration-related protein 2-like isoform X1

    UniProtKB/Swiss-Prot
    Q6NZT2
    UniProtKB/TrEMBL
    A0A8M9P4Y6
    Conserved Domains (1) summary
    cl25732
    Location:13 → 279
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_068215999.1 → XP_068072100.1  cerebellar degeneration-related protein 2-like isoform X1

  3. XM_021469707.2 → XP_021325382.1  cerebellar degeneration-related protein 2-like isoform X1

    UniProtKB/Swiss-Prot
    Q6NZT2
    UniProtKB/TrEMBL
    A0A8M9P4Y6
    Related
    ENSDARP00000105648.2, ENSDART00000128790.3
    Conserved Domains (1) summary
    cl25732
    Location:13 → 279
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NZT2.2 GenPept UniProtKB/Swiss-Prot:Q6NZT2

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