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klhl17 kelch-like family member 17 [ Danio rerio (zebrafish) ]

Gene ID: 336187, updated on 18-Sep-2024

Summary

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Official Symbol
klhl17provided by ZNC
Official Full Name
kelch-like family member 17provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8131
See related
Ensembl:ENSDARG00000037324 AllianceGenome:ZFIN:ZDB-GENE-030131-8131
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fj54g09; si:dkey-98j1.3
Summary
Predicted to be involved in protein ubiquitination. Orthologous to human KLHL17 (kelch like family member 17). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See klhl17 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (23182047..23214599)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (23255486..23288048)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 11 Neighboring gene NOC2-like nucleolar associated transcriptional repressor Neighboring gene pleckstrin homology domain containing, family N member 1 Neighboring gene PPARGC1 and ESRR induced regulator, muscle 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. foxl2 and foxl3 are two ancient paralogs that remain fully functional in teleosts. Crespo B, et al. Gen Comp Endocrinol, 2013 Dec 1. PMID 24045113
  2. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article
  3. Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Armant O, et al. Dev Biol, 2013 Aug 15. PMID 23684812, Free PMC Article
  4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch-like protein 17
Names
kelch-like 17

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    23182047..23214599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003201200.6 → XP_003201248.1  kelch-like protein 17

    See identical proteins and their annotated locations for XP_003201248.1

    UniProtKB/TrEMBL
    A0A8M2B929, E7FB30
    Related
    ENSDARP00000119330.1, ENSDART00000137353.3
    Conserved Domains (4) summary
    smart00612
    Location:528 → 572
    Kelch; Kelch domain
    PHA03098
    Location:41 → 507
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:375 → 418
    Kelch; KELCH repeat [structural motif]
    cd18246
    Location:2 → 140
    BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)

  2. XM_005162205.5 → XP_005162262.1  kelch-like protein 17

    See identical proteins and their annotated locations for XP_005162262.1

    UniProtKB/TrEMBL
    A0A8M2B929, E7FB30
    Related
    ENSDARP00000156064.1, ENSDART00000184920.1
    Conserved Domains (4) summary
    smart00612
    Location:528 → 572
    Kelch; Kelch domain
    PHA03098
    Location:41 → 507
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:375 → 418
    Kelch; KELCH repeat [structural motif]
    cd18246
    Location:2 → 140
    BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395148.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    104471..137023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473681.2 → XP_021329356.1  kelch-like protein 17

    UniProtKB/TrEMBL
    A0A8M2B929, E7FB30
    Conserved Domains (4) summary
    smart00612
    Location:528 → 572
    Kelch; Kelch domain
    PHA03098
    Location:41 → 507
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:375 → 418
    Kelch; KELCH repeat [structural motif]
    cd18246
    Location:2 → 140
    BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)

  2. XM_021473682.2 → XP_021329357.1  kelch-like protein 17

    UniProtKB/TrEMBL
    A0A8M2B929, E7FB30
    Conserved Domains (4) summary
    smart00612
    Location:528 → 572
    Kelch; Kelch domain
    PHA03098
    Location:41 → 507
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:375 → 418
    Kelch; KELCH repeat [structural motif]
    cd18246
    Location:2 → 140
    BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)
Nucleotide Protein Strain
Heading Accession and Version

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