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fred friend of echinoid [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33613, updated on 18-Sep-2024

Summary

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Official Symbol
fredprovided by FlyBase
Official Full Name
friend of echinoidprovided by FlyBase
Primary source
FLYBASE:FBgn0051774
Locus tag
Dmel_CG31774
See related
AllianceGenome:FB:FBgn0051774
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12675; CG31774; CG3390; CG3393; CT11413; Dmel\CG31774; Fred
Summary
Predicted to enable cell adhesion molecule binding activity. Involved in adult chitin-based cuticle pattern formation; compound eye morphogenesis; and regulation of establishment of planar polarity. Predicted to be active in cell-cell junction. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adult head; imaginal disc; and presumptive embryonic/larval system. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See fred in Genome Data Viewer
Location:
24C9-24D2; 2-11 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3902928..3991713, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3902928..3991713, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Centrosomal protein 97kDa Neighboring gene uncharacterized protein Neighboring gene cappuccino Neighboring gene Folylpolyglutamate synthase 2 Neighboring gene long non-coding RNA:CR45344 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Echinoid is an antagonist of Egfr signalling, but is not a member of the L1-type family of cell adhesion molecules. Hortsch M. Development, 2003 Nov. PMID 14530293
  2. Modulation of early olfactory processing by an octopaminergic reinforcement pathway in the honeybee. Farooqui T, et al. J Neurosci, 2003 Jun 15. PMID 12832563, Free PMC Article
  3. Differential adhesion and actomyosin cable collaborate to drive Echinoid-mediated cell sorting. Chang LH, et al. Development, 2011 Sep. PMID 21795280
  4. The Drosophila IgC2 domain protein Friend-of-Echinoid, a paralogue of Echinoid, limits the number of sensory organ precursors in the wing disc and interacts with the Notch signaling pathway. Chandra S, et al. Dev Biol, 2003 Apr 15. PMID 12679104
  5. EGF receptor signaling: a prickly proposition. Firth LC, et al. Curr Biol, 2003 Sep 30. PMID 14521857

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. differential levels of Ed and Fred between stationary and rotating cells at the initiation of rotation create a permissive environment for cell movement, and uniform levels in these two populations later contribute to stopping the movement
    Title: The cell adhesion molecules Echinoid and Friend of Echinoid coordinate cell adhesion and cell signaling to regulate the fidelity of ommatidial rotation in the Drosophila eye.
  2. acts in close concert with the Notch signaling pathway
    Title: The Drosophila IgC2 domain protein Friend-of-Echinoid, a paralogue of Echinoid, limits the number of sensory organ precursors in the wing disc and interacts with the Notch signaling pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adult chitin-based cuticle pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of establishment of planar polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
friend of echinoid
Names
CG31774-PF
CG31774-PG
CG31774-PH
fred-PF
fred-PG
fred-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3902928..3991713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258937.2 → NP_001245866.1  friend of echinoid, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245866.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4LU27, M9NCR3
    Conserved Domains (7) summary
    cd00096
    Location:635 → 713
    Ig; Immunoglobulin domain
    smart00408
    Location:330 → 385
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141 → 228
    IG_like; Immunoglobulin like
    cd00063
    Location:720 → 838
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:232 → 313
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:416 → 501
    Ig_2; Immunoglobulin domain
    cl11960
    Location:147 → 228
    Ig; Immunoglobulin domain

  2. NM_164569.4 → NP_722954.3  friend of echinoid, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722954.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IXX2, Q9VQW1
    Conserved Domains (7) summary
    cd00096
    Location:635 → 713
    Ig; Immunoglobulin domain
    smart00408
    Location:330 → 385
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141 → 228
    IG_like; Immunoglobulin like
    cd00063
    Location:720 → 838
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:232 → 313
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:416 → 501
    Ig_2; Immunoglobulin domain
    cl11960
    Location:147 → 228
    Ig; Immunoglobulin domain

  3. NM_134968.4 → NP_608812.3  friend of echinoid, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608812.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A023GPK8
    Conserved Domains (7) summary
    cd00096
    Location:635 → 713
    Ig; Immunoglobulin domain
    smart00408
    Location:330 → 385
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141 → 228
    IG_like; Immunoglobulin like
    cd00063
    Location:720 → 838
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:232 → 313
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:416 → 501
    Ig_2; Immunoglobulin domain
    cl11960
    Location:147 → 228
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A023GPK8 A0A023GPK8
M9NCR3 M9NCR3
Q8MZ57 Q8MZ57
Q9VQW1 Q9VQW1

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