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bark bark beetle [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33604, updated on 4-Apr-2024

Summary

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Official Symbol
barkprovided by FlyBase
Official Full Name
bark beetleprovided by FlyBase
Primary source
FLYBASE:FBgn0031571
Locus tag
Dmel_CG3921
See related
AllianceGenome:FB:FBgn0031571
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aka; Aka; Bark; CG3921; Dmel\CG3921
Summary
Predicted to enable carbohydrate binding activity. Involved in cell-cell junction organization; open tracheal system development; and response to endoplasmic reticulum stress. Located in lateral plasma membrane; septate junction; and tricellular tight junction. Is expressed in several structures, including embryonic/larval tracheal system; epithelium; gut section; spermatozoon; and yolk nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See bark in Genome Data Viewer
Location:
24C4-24C5; 2-11 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3787167..3802726)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3787167..3802726)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Regulator of eph expression Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Scribble and Discs Large mediate tricellular junction formation. Sharifkhodaei Z, et al. Development, 2019 Sep 23. PMID 31444218
  2. The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila. Wittek A, et al. Curr Biol, 2020 Nov 2. PMID 32857972
  3. Coordination of Septate Junctions Assembly and Completion of Cytokinesis in Proliferative Epithelial Tissues. Daniel E, et al. Curr Biol, 2018 May 7. PMID 29706514
  4. The claudin Megatrachea protein complex. Jaspers MH, et al. J Biol Chem, 2012 Oct 26. PMID 22930751, Free PMC Article
  5. The Triple-Repeat Protein Anakonda Controls Epithelial Tricellular Junction Formation in Drosophila. Byri S, et al. Dev Cell, 2015 Jun 8. PMID 25982676

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila.
    Title: The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila.
  2. Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium.
    Title: Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium.
  3. Disentanglement of the neighbour cells from the midbody, and the midbody movement, are impaired in the absence of the Gliotactin (Gli) and Anakonda (Aka) TCJ proteins.
    Title: Tricellular junction proteins promote disentanglement of daughter and neighbour cells during epithelial cytokinesis.
  4. Study describes the identification and functional characterisation of the putative scavenger receptor-like protein Bark beetle (Bark; CG3921) Bark is required for septate junction (SJ) maturation in developing epithelial cells, in addition Bark controls epithelial cell adhesion within the SJ compartment.
    Title: Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbohydrate binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell junction maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in liquid clearance, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube length, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to endoplasmic reticulum stress HMP PubMed 
involved_in tricellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in septate junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in septate junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in tricellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bark beetle
Names
CG3921-PA
CG3921-PB
CG3921-PC
anakonda
bark-PA
bark-PB
bark-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3787167..3802726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258935.3 → NP_001245864.1  bark beetle, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245864.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NDE3, Q9VQV1
    Conserved Domains (5) summary
    smart00034
    Location:2604 → 2699
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00202
    Location:1071 → 1175
    SR; Scavenger receptor Cys-rich
    cd00041
    Location:459 → 552
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00530
    Location:1076 → 1174
    SRCR; Scavenger receptor cysteine-rich domain
    pfam13229
    Location:579 → 752
    Beta_helix; Right handed beta helix region

  2. NM_134964.4 → NP_608808.1  bark beetle, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608808.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NDE3
    Related
    FBpp0077185
    Conserved Domains (5) summary
    smart00034
    Location:2596 → 2691
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00202
    Location:1071 → 1175
    SR; Scavenger receptor Cys-rich
    cd00041
    Location:459 → 552
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00530
    Location:1076 → 1174
    SRCR; Scavenger receptor cysteine-rich domain
    pfam13229
    Location:579 → 752
    Beta_helix; Right handed beta helix region

  3. NM_001258936.2 → NP_001245865.1  bark beetle, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245865.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NDE3, Q9VQV1
    Conserved Domains (5) summary
    smart00034
    Location:2604 → 2699
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00202
    Location:1071 → 1175
    SR; Scavenger receptor Cys-rich
    cd00041
    Location:459 → 552
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00530
    Location:1076 → 1174
    SRCR; Scavenger receptor cysteine-rich domain
    pfam13229
    Location:579 → 752
    Beta_helix; Right handed beta helix region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NDE3.1 M9NDE3

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