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Pif1 Pif1 DNA helicase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33567, updated on 28-Oct-2024

Summary

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Official Symbol
Pif1provided by FlyBase
Official Full Name
Pif1 DNA helicaseprovided by FlyBase
Primary source
FLYBASE:FBgn0031540
Locus tag
Dmel_CG3238
See related
AllianceGenome:FB:FBgn0031540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3238; Dmel\CG3238; pif1
Summary
Predicted to enable 5'-3' DNA helicase activity. Involved in double-strand break repair via break-induced replication. Predicted to be active in replication fork. Is expressed in organism. Orthologous to human PIF1 (PIF1 5'-to-3' DNA helicase). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See Pif1 in Genome Data Viewer
Location:
23F3-23F3; 2-10 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3467342..3470004, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3467342..3470004, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene male-specific lethal 2 Neighboring gene mir-4971 stem loop Neighboring gene NADH dehydrogenase (ubiquinone) PDSW subunit Neighboring gene uncharacterized protein Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila PIF1 functions with POL32 during times of replication stress but acts independently of POL32 to promote synthesis during double-strand gap repair.
    Title: The Drosophila melanogaster PIF1 Helicase Promotes Survival During Replication Stress and Processive DNA Synthesis During Double-Strand Gap Repair.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5'-3' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via break-induced replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Pif1 DNA helicase
Names
CG3238-PA
CG3238-PB
Pif1 helicase
Pif1 ortholog
Pif1-PA
Pif1-PB
NP_001285587.1
NP_608782.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3467342..3470004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298658.1 → NP_001285587.1  Pif1 DNA helicase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285587.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQR3
    Conserved Domains (1) summary
    cl21455
    Location:205 → 510
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_134938.3 → NP_608782.1  Pif1 DNA helicase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608782.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VQR3
    Related
    FBpp0077258
    Conserved Domains (1) summary
    cl21455
    Location:205 → 510
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQR3 Q9VQR3

Gene LinkOut

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