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Cog3 Component of oligomeric golgi complex 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33562, updated on 18-Sep-2024

Summary

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Official Symbol
Cog3provided by FlyBase
Official Full Name
Component of oligomeric golgi complex 3provided by FlyBase
Primary source
FLYBASE:FBgn0031536
Locus tag
Dmel_CG3248
See related
AllianceGenome:FB:FBgn0031536
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG 3248; CG3248; COG3; dCOG3; Dmel\CG3248; SEC34
Summary
Involved in dsRNA transport and male meiosis cytokinesis. Part of Golgi transport complex. Is expressed in several structures, including adult head; gut section; and spermatozoon. Orthologous to human COG3 (component of oligomeric golgi complex 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Cog3 in Genome Data Viewer
Location:
23F3-23F3; 2-10 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3453697..3457064, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3453697..3457064, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 1 Neighboring gene uncharacterized protein Neighboring gene Secretory 5 Neighboring gene uncharacterized protein Neighboring gene male-specific lethal 2 Neighboring gene mir-4971 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. dGRASP localization and function in the early exocytic pathway in Drosophila S2 cells. Kondylis V, et al. Mol Biol Cell, 2005 Sep. PMID 15975913, Free PMC Article
  2. Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis. Belloni G, et al. J Cell Sci, 2012 Nov 15. PMID 22946051, Free PMC Article
  3. Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation. Smith RD, et al. Carbohydr Res, 2008 Aug 11. PMID 18353293, Free PMC Article
  4. The exocyst component Sec5 is present on endocytic vesicles in the oocyte of Drosophila melanogaster. Sommer B, et al. J Cell Biol, 2005 Jun 20. PMID 15955846, Free PMC Article
  5. The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Saleh MC, et al. Nat Cell Biol, 2006 Aug. PMID 16862146, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dsRNA transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in male meiosis cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Golgi transport complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Golgi transport complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cis-Golgi network IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
component of oligomeric golgi complex 3
Names
CG3248-PA
Cog3-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3453697..3457064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134935.3 → NP_608779.1  component of oligomeric golgi complex 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608779.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q961G1, Q9VQQ8
    Related
    FBpp0077262
    Conserved Domains (1) summary
    pfam04136
    Location:117 → 261
    Sec34; Sec34-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q961G1.1 Q961G1

Gene LinkOut

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