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GramD1B GRAM domain containing 1B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33552, updated on 2-Nov-2024

Summary

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Official Symbol
GramD1Bprovided by FlyBase
Official Full Name
GRAM domain containing 1Bprovided by FlyBase
Primary source
FLYBASE:FBgn0085423
Locus tag
Dmel_CG34394
See related
AllianceGenome:FB:FBgn0085423
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE58243; CG15411; CG3304; CG34394; Dmel\CG34394
Old locus tag
CG15411; CG3304; Dmel_CG15411; Dmel_CG3304
Summary
Predicted to enable sterol binding activity and sterol transfer activity. Predicted to be involved in intracellular sterol transport. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Is expressed in adult head; embryonic/larval Malpighian tubule; embryonic/larval gut; and larval brain. Orthologous to several human genes including GRAMD1C (GRAM domain containing 1C). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See GramD1B in Genome Data Viewer
Location:
23E5-23F1; 2-9 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3358640..3373372, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3358640..3373372, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Early gene at 23 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GRAM domain-containing protein 1B (GRAMD1B), a novel component of the JAK/STAT signaling pathway, functions in gastric carcinogenesis. Khanna P, et al. Oncotarget, 2017 Dec 29. PMID 29383166, Free PMC Article
  2. Deep sequencing of the prothoracic gland transcriptome reveals new players in insect ecdysteroidogenesis. Nakaoka T, et al. PLoS One, 2017. PMID 28257485, Free PMC Article
  3. Comparative transcriptional profiling and evolutionary analysis of the GRAM domain family in eukaryotes. Jiang SY, et al. Dev Biol, 2008 Feb 15. PMID 18201690
  4. Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila. Hazelett DJ, et al. G3 (Bethesda), 2012 Jul. PMID 22870402, Free PMC Article
  5. Genome features of "Dark-fly", a Drosophila line reared long-term in a dark environment. Izutsu M, et al. PLoS One, 2012. PMID 22432011, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-plasma membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GRAM domain containing 1B
Names
CG34394-PA
CG34394-PC
CG34394-PD
CG34394-PE
CG34394-PG
CG34394-PH
GramD1B-PA
GramD1B-PC
GramD1B-PD
GramD1B-PE
GramD1B-PG
GramD1B-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3358640..3373372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134926.4 → NP_608770.4  GRAM domain containing 1B, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608770.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    R9PY34
    Conserved Domains (2) summary
    cd13220
    Location:324 → 417
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:717 → 863
    DUF4782; Domain of unknown function (DUF4782)

  2. NM_001103598.3 → NP_001097068.1  GRAM domain containing 1B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097068.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYU1
    Conserved Domains (2) summary
    cd13220
    Location:422 → 515
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:815 → 961
    DUF4782; Domain of unknown function (DUF4782)

  3. NM_205901.3 → NP_995623.2  GRAM domain containing 1B, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995623.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    R9PY62
    Conserved Domains (2) summary
    cd13220
    Location:358 → 451
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:751 → 897
    DUF4782; Domain of unknown function (DUF4782)

  4. NM_001103599.3 → NP_001097069.1  GRAM domain containing 1B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097069.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYU2
    Conserved Domains (2) summary
    cd13220
    Location:348 → 441
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:741 → 887
    DUF4782; Domain of unknown function (DUF4782)

  5. NM_001103601.3 → NP_001097071.1  GRAM domain containing 1B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097071.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYU3
    Conserved Domains (2) summary
    cd13220
    Location:348 → 441
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:741 → 887
    DUF4782; Domain of unknown function (DUF4782)

  6. NM_001258927.1 → NP_001245856.1  GRAM domain containing 1B, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245856.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NE71
    Conserved Domains (1) summary
    pfam16016
    Location:306 → 452
    DUF4782; Domain of unknown function (DUF4782)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYU1 A8DYU1
A8DYU2 A8DYU2
A8DYU3 A8DYU3
M9NE71 M9NE71
Q8IGN7 Q8IGN7
Q8MRR1 Q8MRR1
R9PY34 R9PY34
R9PY62 R9PY62

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