U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ppiab peptidylprolyl isomerase Ab (cyclophilin A) [ Danio rerio (zebrafish) ]

Gene ID: 335519, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ppiabprovided by ZNC
Official Full Name
peptidylprolyl isomerase Ab (cyclophilin A)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7459
See related
Ensembl:ENSDARG00000103994 AllianceGenome:ZFIN:ZDB-GENE-030131-7459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ppial; zgc:73102; zgc:86688; wu:fj18g05
Summary
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within response to hypoxia. Predicted to be located in extracellular region. Predicted to be active in mitochondrion and nucleus. Is expressed in brain. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ppiab in Genome Data Viewer
Location:
chromosome: 10
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (45345574..45352279)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (45498962..45505667)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) glycohydrolase, like Neighboring gene zinc finger, MIZ-type containing 2 Neighboring gene RING finger protein 122 Neighboring gene kinesin-like protein KIF2A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transient, flexible gene editing in zebrafish neutrophils and macrophages for determination of cell-autonomous functions. Isiaku AI, et al. Dis Model Mech, 2021 Jul 1. PMID 34296745, Free PMC Article
  2. The afc antifungal activity cluster, which is under tight regulatory control of ShvR, is essential for transition from intracellular persistence of Burkholderia cenocepacia to acute pro-inflammatory infection. Gomes MC, et al. PLoS Pathog, 2018 Dec. PMID 30513124, Free PMC Article
  3. Hif-1α-Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish. Ogryzko NV, et al. J Immunol, 2019 Jan 15. PMID 30552162, Free PMC Article
  4. Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation. Mesureur J, et al. PLoS Pathog, 2017 Jun. PMID 28651010, Free PMC Article
  5. The Role of Galanin during Bacterial Infection in Larval Zebrafish. Nowik N, et al. Cells, 2021 Aug 6. PMID 34440783, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein folding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to hypoxia IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
peptidylprolyl isomerase Ab (cyclophilin A)
Names
cyclophilin
peptidylprolyl isomerase A, like
NP_001315353.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328424.1 → NP_001315353.1  peptidylprolyl isomerase Ab (cyclophilin A)

    Status: VALIDATED

    Source sequence(s)
    CF998539, EH487851, FP074878
    UniProtKB/TrEMBL
    A0A0R4IM14, Q6IQN4, Q6PC53
    Related
    ENSDARP00000134856.1, ENSDART00000166085.2
    Conserved Domains (1) summary
    cd01926
    Location:4 → 162
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    45345574..45352279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199957.1: Suppressed sequence

    Description
    NM_199957.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous