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GABPI beta4GalNAcTB pilot [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33516, updated on 18-Sep-2024

Summary

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Official Symbol
GABPIprovided by FlyBase
Official Full Name
beta4GalNAcTB pilotprovided by FlyBase
Primary source
FLYBASE:FBgn0031495
Locus tag
Dmel_CG17257
See related
AllianceGenome:FB:FBgn0031495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17257; Dmel\CG17257
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus. Is expressed in several structures, including adult head; central nervous system; embryonic/larval gut; and endoderm. Orthologous to human ZDHHC23 (zinc finger DHHC-type palmitoyltransferase 23). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See GABPI in Genome Data Viewer
Location:
23C5-23C5; 2-8 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3030539..3032300)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3030539..3032300)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene alpha1,4-galactosyltransferase 1 Neighboring gene pre-mRNA processing factor 40 Neighboring gene Splicing factor 3b subunit 2 Neighboring gene antisense RNA:CR44147 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Seryl-tRNA synthetase Neighboring gene uncharacterized protein Neighboring gene cornichon related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. "Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein. Kraft B, et al. Cell Mol Life Sci, 2011 Dec. PMID 21598021, Free PMC Article
  2. Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot. Johswich A, et al. J Cell Biol, 2009 Jan 12. PMID 19139268, Free PMC Article
  3. The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes. Porcellato E, et al. PLoS One, 2022. PMID 35960718, Free PMC Article
  4. The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. Bannan BA, et al. Fly (Austin), 2008 Jul-Aug. PMID 18719403, Free PMC Article
  5. Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome. Grimberg KB, et al. Mol Cell Biol, 2011 Feb. PMID 21149573, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lumenal loop regions are insect-conserved and essential for GABPI-b4GalNAcTB interaction.
    Title: "Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein.
  2. beta4GalNAcTB pilot (GABPI) is required for ER export and activity of beta4GalNAcTB.
    Title: Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
beta4GalNAcTB pilot
Names
CG17257-PA
CG17257-PB
CG17257-PC
CG17257-PD
GABPI-PA
GABPI-PB
GABPI-PC
GABPI-PD
NP_001285573.1
NP_001285574.1
NP_608741.1
NP_722869.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3030539..3032300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298644.1 → NP_001285573.1  beta4GalNAcTB pilot, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285573.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J6Q6
    Conserved Domains (1) summary
    pfam01529
    Location:185 → 322
    zf-DHHC; DHHC palmitoyltransferase

  2. NM_164522.3 → NP_722869.1  beta4GalNAcTB pilot, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0C4, Q9VQK9
    Related
    FBpp0077337
    Conserved Domains (1) summary
    pfam01529
    Location:262 → 399
    zf-DHHC; DHHC palmitoyltransferase

  3. NM_134897.5 → NP_608741.1  beta4GalNAcTB pilot, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608741.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0C4, Q9VQK9
    Related
    FBpp0077336
    Conserved Domains (1) summary
    pfam01529
    Location:262 → 399
    zf-DHHC; DHHC palmitoyltransferase

  4. NM_001298645.1 → NP_001285574.1  beta4GalNAcTB pilot, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285574.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J6Q6
    Conserved Domains (1) summary
    pfam01529
    Location:185 → 322
    zf-DHHC; DHHC palmitoyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQK9 Q9VQK9
X2J6Q6 X2J6Q6

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