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colt congested-like trachea [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33470, updated on 2-Nov-2024

Summary

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Official Symbol
coltprovided by FlyBase
Official Full Name
congested-like tracheaprovided by FlyBase
Primary source
FLYBASE:FBgn0019830
Locus tag
Dmel_CG3057
See related
AllianceGenome:FB:FBgn0019830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CACT; CG3057; Colt; Dmel\CG3057
Summary
Predicted to enable acyl carnitine transmembrane transporter activity. Involved in epithelial cell morphogenesis and liquid clearance, open tracheal system. Predicted to be located in membrane. Predicted to be active in mitochondrial envelope. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in carnitine-acylcarnitine translocase deficiency. Orthologous to human SLC25A20 (solute carrier family 25 member 20). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See colt in Genome Data Viewer
Location:
23A5-23A5; 2-7 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2768590..2770069, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2768590..2770069, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene anterior pharynx defective 1 Neighboring gene TBP-associated factor 10b Neighboring gene TBP-associated factor 10 Neighboring gene uncharacterized protein Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene Synaptotagmin 1 Neighboring gene long non-coding RNA:CR43821

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Medium-Chain Fatty Acids, Beta-Hydroxybutyric Acid and Genetic Modulation of the Carnitine Shuttle Are Protective in a Drosophila Model of ALS Based on TDP-43. Manzo E, et al. Front Mol Neurosci, 2018. PMID 29904341, Free PMC Article
  2. A novel Drosophila mitochondrial carrier protein acts as a Mg(2+) exporter in fine-tuning mitochondrial Mg(2+) homeostasis. Cui Y, et al. Biochim Biophys Acta, 2016 Jan. PMID 26462626
  3. The Reversible Carnitine Palmitoyltransferase 1 Inhibitor (Teglicar) Ameliorates the Neurodegenerative Phenotype in a Drosophila Huntington's Disease Model by Acting on the Expression of Carnitine-Related Genes. Bertapelle C, et al. Molecules, 2022 May 13. PMID 35630602, Free PMC Article
  4. The congested-like tracheae gene of Drosophila melanogaster encodes a member of the mitochondrial carrier family required for gas-filling of the tracheal system and expansion of the wings after eclosion. Hartenstein K, et al. Genetics, 1997 Dec. PMID 9409834, Free PMC Article
  5. Two novel Drosophila TAF(II)s have homology with human TAF(II)30 and are differentially regulated during development. Georgieva S, et al. Mol Cell Biol, 2000 Mar. PMID 10669741, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyl carnitine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carnitine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in liquid clearance, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in mitochondrial envelope IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
congested-like trachea
Names
CG3057-PA
CG3057-PD
carnitine Acyl-Carnitine translocase
collapsed trachea
colt-PA
colt-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2768590..2770069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057873.5 → NP_477221.1  congested-like trachea, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477221.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V020, O01396, Q9VQG4
    Related
    FBpp0077414
    Conserved Domains (1) summary
    pfam00153
    Location:12 → 107
    Mito_carr; Mitochondrial carrier protein

  2. NM_205894.1 → NP_995616.1  congested-like trachea, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995616.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V020, O01396, Q9VQG4
    Conserved Domains (1) summary
    pfam00153
    Location:12 → 107
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQG4.1 Q9VQG4

Gene LinkOut

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