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Taf10 TBP-associated factor 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33469, updated on 2-Nov-2024

Summary

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Official Symbol
Taf10provided by FlyBase
Official Full Name
TBP-associated factor 10provided by FlyBase
Primary source
FLYBASE:FBgn0028398
Locus tag
Dmel_CG2859
See related
AllianceGenome:FB:FBgn0028398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE73934; CG2859; Dmel\CG2859; dmTaf10; dmTAF10; dTAF10; dtafII24; dTAFII24; dTAF[[II]]24; TAF; taf10; TAF10; taf24; Taf24; TafII24; TAF[[II]]; TAF[[II]]24; TFIID
Summary
Contributes to RNA polymerase II general transcription initiation factor activity. Involved in transcription initiation at RNA polymerase II promoter. Located in cytoplasm and nucleus. Part of transcription factor TFIID complex. Is expressed in several structures, including anal pad primordium; ectoderm; embryonic cortex; embryonic epidermis; and ganglia. Orthologous to human TAF10 (TATA-box binding protein associated factor 10). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Taf10 in Genome Data Viewer
Location:
23A5-23A5; 2-7 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2767890..2768612)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2767890..2768612)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene anterior pharynx defective 1 Neighboring gene TBP-associated factor 10b Neighboring gene congested-like trachea Neighboring gene uncharacterized protein Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene Synaptotagmin 1 Neighboring gene long non-coding RNA:CR43821

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TAF10 and TAF10b partially redundant roles during Drosophila melanogaster morphogenesis. Pahi Z, et al. Transcription, 2017. PMID 28841365, Free PMC Article
  2. [Conservative E(y)2/Sus1 protein is the member of SAGA complex and new nuclear pore-associated complex in Drosophila]. Kurshakova MM, et al. Genetika, 2009 Oct. PMID 19947544
  3. Two novel Drosophila TAF(II)s have homology with human TAF(II)30 and are differentially regulated during development. Georgieva S, et al. Mol Cell Biol, 2000 Mar. PMID 10669741, Free PMC Article
  4. Study of the properties of two homologues of yeast ADA2 in Drosophila melanogaster. Lebedeva LA, et al. Dokl Biochem Biophys, 2004 Sep-Oct. PMID 15584512
  5. Prodos is a conserved transcriptional regulator that interacts with dTAF(II)16 in Drosophila melanogaster. Hernández-Hernández A, et al. Mol Cell Biol, 2001 Jan. PMID 11134347, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report shows the functional similarities and differences of TAF10 and TAF10b, orthologs of Drosophila melanogaster. In silico modeling suggest that dTAF10 and dTAF10b have similar secondary structures with a histone-fold domain, same interaction partners and similar expression patterns in neuronal tissues. dTaf10 isn't required for morphogenesis, but animals lacking its expression show distorted eye development.
    Title: TAF10 and TAF10b partially redundant roles during Drosophila melanogaster morphogenesis.
  2. The lack of both dTAF10 proteins resulted in failures in the larval-pupal transition during metamorphosis and in transcriptional reprogramming at this developmental stage.
    Title: dTAF10- and dTAF10b-Containing Complexes Are Required for Ecdysone-Driven Larval-Pupal Morphogenesis in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
TBP-associated factor 10
Names
CG2859-PA
TBP-associated factor
TBP-associated factor 24kD
Taf10-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2767890..2768612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058115.5 → NP_477463.1  TBP-associated factor 10 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477463.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U5W9, Q9VQG3
    Related
    FBpp0077401
    Conserved Domains (1) summary
    cd07982
    Location:56 → 166
    TAF10; The TATA Binding Protein (TBP) Associated Factor 10
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U5W9.2 Q9U5W9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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