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form3 formin 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3346238, updated on 27-Feb-2024

Summary

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Official Symbol
form3provided by FlyBase
Official Full Name
formin 3provided by FlyBase
Primary source
FLYBASE:FBgn0053556
Locus tag
Dmel_CG33556
See related
AllianceGenome:FB:FBgn0053556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ah1644; CG14824; CG18138; CG32384; CG33556; CG8633; Dmel\CG33556; form; Form3; formin/DIA-like; Formin3; INF2
Summary
Predicted to enable actin binding activity. Involved in branch fusion, open tracheal system. Is expressed in presumptive embryonic/larval system; spermatozoon; and tracheocyte. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate E and focal segmental glomerulosclerosis 5. Orthologous to several human genes including FHDC1 (FH2 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
65E3-65E4; 3-19 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7094818..7123297)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7087918..7116397)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 65Eb Neighboring gene Cuticular protein 65Ec Neighboring gene male-specific lethal 3 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene Acyl-CoA binding protein 4 Neighboring gene Acyl-CoA binding protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct Relations of Microtubules and Actin Filaments with Dendritic Architecture. Nanda S, et al. iScience, 2020 Dec 18. PMID 33319182, Free PMC Article
  2. A Comparative Study of the Role of Formins in Drosophila Embryonic Dorsal Closure. Tóth K, et al. Cells, 2022 May 4. PMID 35563844, Free PMC Article
  3. Epistasis for head morphology in Drosophila melanogaster. Özsoy ED, et al. G3 (Bethesda), 2021 Sep 27. PMID 34568933, Free PMC Article
  4. Polyglutamine repeat proteins disrupt actin structure in Drosophila photoreceptors. Vu A, et al. Mol Cell Neurosci, 2018 Dec. PMID 30149064
  5. Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior. Das R, et al. Development, 2021 Aug 15. PMID 34322714, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior.
    Title: Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior.
  2. find that Form3 has additional functions in photoreceptors, and that loss of Form3 results in the specification of extra photoreceptors in the eye
    Title: Polyglutamine repeat proteins disrupt actin structure in Drosophila photoreceptors.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in branch fusion, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular component organization IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
formin 3
Names
CG33556-PA
CG33556-PB
form3-PA
form3-PB
formin3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7094818..7123297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104057.1 → NP_001097527.1  formin 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097527.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNM1
    Conserved Domains (3) summary
    pfam02181
    Location:415 → 803
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:48 → 309
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:1 → 43
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. NM_001014571.1 → NP_001014571.1  formin 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014571.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86C16
    Conserved Domains (3) summary
    pfam02181
    Location:342 → 730
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:48 → 236
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:1 → 43
    Drf_GBD; Diaphanous GTPase-binding Domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JNM1 A8JNM1
Q86C16 Q86C16
Q86NV5 Q86NV5

Gene LinkOut

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