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btsz bitesize [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3346167, updated on 2-Nov-2024

Summary

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Official Symbol
btszprovided by FlyBase
Official Full Name
bitesizeprovided by FlyBase
Primary source
FLYBASE:FBgn0266756
Locus tag
Dmel_CG44012
See related
AllianceGenome:FB:FBgn0266756
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH06647; Btsz; CG14858; CG17304; CG18280; CG31306; CG33555; CG44012; CG7343; Dmel\CG44012; Granulophilin; l(3)10418
Old locus tag
Dmel_CG17304; Dmel_CG33555
Summary
Predicted to enable neurexin family protein binding activity. Involved in several processes, including actin cytoskeleton organization; embryonic morphogenesis; and larval salivary gland morphogenesis. Located in apical plasma membrane. Is expressed in several structures, including adult head; dorsal ectoderm; dorsal ectoderm anlage; epithelium; and gut section. Orthologous to human SYTL1 (synaptotagmin like 1); SYTL4 (synaptotagmin like 4); and SYTL5 (synaptotagmin like 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See btsz in Genome Data Viewer
Location:
88D4-88D6; 3-56 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14804092..14875488, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10629814..10701210, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46024 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rrp6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame. Serano J, et al. Proc Natl Acad Sci U S A, 2003 Nov 11. PMID 14581614, Free PMC Article
  2. Re-solving the cadherin-catenin-actin conundrum. Weis WI, et al. J Biol Chem, 2006 Nov 24. PMID 17005550, Free PMC Article
  3. CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles. Cavalheiro GR, et al. Sci Adv, 2023 Feb 3. PMID 36735786, Free PMC Article
  4. An endosome-associated actin network involved in directed apical plasma membrane growth. Ríos-Barrera LD, et al. J Cell Biol, 2022 Mar 7. PMID 35061016, Free PMC Article
  5. Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz. Pilot F, et al. Nature, 2006 Aug 3. PMID 16862128

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Btsz and Moesin guide luminal membrane morphogenesis through organizing actin.
    Title: Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin.
  2. found that bitesize is a metazoan example of a transcript for which all identifiable mRNA localization sequences are contained within the protein-coding region
    Title: The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame.
  3. data indicate that, through their interaction, Btsz and Moesin may mediate the proper organization of actin in a local domain, which in turn stabilizes E-cadherin
    Title: Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables neurexin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apical junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of planar polarity of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gastrulation involving germ band extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in larval salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lumen formation, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bitesize
Names
CG44012-PB
CG44012-PC
CG44012-PD
CG44012-PE
CG44012-PF
CG44012-PG
CG44012-PH
CG44012-PI
CG44012-PJ
bite size
btsz-PB
btsz-PC
btsz-PD
btsz-PE
btsz-PF
btsz-PG
btsz-PH
btsz-PI
btsz-PJ
granulophilin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14804092..14875488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014622.3 → NP_001014622.3  bitesize, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014622.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59DX2
    Conserved Domains (4) summary
    cd04020
    Location:1367 → 1556
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08521
    Location:1231 → 1353
    C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins
    cd15747
    Location:239 → 286
    FYVE_Slp3_4_5; FYVE-related domain found in the synaptotagmin-like proteins 3, 4, 5
    pfam15279
    Location:514 → 689
    SOBP; Sine oculis-binding protein

  2. NM_001275653.1 → NP_001262582.1  bitesize, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262582.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59DX2
    Conserved Domains (4) summary
    cd04020
    Location:1367 → 1556
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08521
    Location:1231 → 1353
    C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins
    cd15747
    Location:239 → 286
    FYVE_Slp3_4_5; FYVE-related domain found in the synaptotagmin-like proteins 3, 4, 5
    pfam15279
    Location:514 → 689
    SOBP; Sine oculis-binding protein

  3. NM_001014625.3 → NP_001014625.1  bitesize, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014625.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6XK20
    Conserved Domains (3) summary
    cd04020
    Location:902 → 1091
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08521
    Location:766 → 888
    C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins
    pfam15279
    Location:49 → 224
    SOBP; Sine oculis-binding protein

  4. NM_001144584.3 → NP_001138056.1  bitesize, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138056.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0K1
    Conserved Domains (3) summary
    cd04020
    Location:937 → 1126
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08521
    Location:801 → 923
    C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins
    pfam15279
    Location:49 → 224
    SOBP; Sine oculis-binding protein

  5. NM_001260180.2 → NP_001247109.1  bitesize, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247109.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K657
    Conserved Domains (4) summary
    cd04020
    Location:3534 → 3723
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08521
    Location:3398 → 3520
    C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins
    cd15747
    Location:26 → 73
    FYVE_Slp3_4_5; FYVE-related domain found in the synaptotagmin-like proteins 3, 4, 5
    pfam15279
    Location:300 → 476
    SOBP; Sine oculis-binding protein

  6. NM_001014624.3 → NP_001014624.1  bitesize, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014624.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6XK19
    Conserved Domains (2) summary
    cd04020
    Location:2445 → 2634
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08521
    Location:2309 → 2431
    C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins

  7. NM_001014623.3 → NP_001014623.1  bitesize, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014623.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59DW9, Q6XK18
    Conserved Domains (2) summary
    cd04020
    Location:1317 → 1506
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08521
    Location:1181 → 1303
    C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins

  8. NM_001144583.3 → NP_001138055.1  bitesize, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138055.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0K2, Q1EBZ7
    Conserved Domains (2) summary
    cd04020
    Location:400 → 589
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08521
    Location:264 → 386
    C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins

  9. NM_001104324.4 → NP_001097794.1  bitesize, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097794.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JR10
    Conserved Domains (2) summary
    cd04020
    Location:508 → 697
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd08521
    Location:372 → 494
    C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K657 A0A0B4K657
A8JR10 A8JR10
B7Z0K1 B7Z0K1
B7Z0K2 B7Z0K2
Q2XYH6 Q2XYH6
Q59DW9 Q59DW9
Q59DX2 Q59DX2
Q6XK18 Q6XK18
Q6XK19 Q6XK19
Q6XK20 Q6XK20
Q8MSJ8 Q8MSJ8

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