U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pgk Phosphoglycerate kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33461, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Pgkprovided by FlyBase
Official Full Name
Phosphoglycerate kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0250906
Locus tag
Dmel_CG3127
See related
AllianceGenome:FB:FBgn0250906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
169C9S; anon-sts18; CG3127; Dmel\CG3127; ESTS:169C9S; l(2)23AB3; l(2)23Ac; pgk; PGK; pgk1
Summary
Predicted to enable ADP binding activity; ATP binding activity; and phosphoglycerate kinase activity. Involved in canonical glycolysis; chemical synaptic transmission; and muscle cell cellular homeostasis. Located in M band and Z disc. Is expressed in several structures, including adult head; adult heart; larval muscle system; and muscle cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in hemolytic anemia and phosphoglycerate kinase 1 deficiency. Orthologous to several human genes including PGK2 (phosphoglycerate kinase 2). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pgk in Genome Data Viewer
Location:
23A3-23A3; 2-7 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2746880..2753068, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2746880..2753068, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-4914 stem loop Neighboring gene Hepatocyte growth factor regulated tyrosine kinase substrate Neighboring gene uncharacterized protein Neighboring gene Cwc25 Neighboring gene Bacchus Neighboring gene long non-coding RNA:CR44772 Neighboring gene SNAP associated protein Neighboring gene HemK methyltransferase 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-binding sites. Nagao M, et al. FEBS Lett, 1996 Jun 3. PMID 8674541
  2. Structure and expression of the phosphoglycerate kinase (Pgk) gene of Drosophila melanogaster. Roselli-Rehfuss L, et al. Mol Gen Genet, 1992 Nov. PMID 1465095
  3. Phosphoglycerate kinas polymorphism in Drosophila. Chew GK, et al. Biochem Genet, 1973 Mar. PMID 4633878
  4. Regulation of phase separation and antiviral activity of Cactin by glycolytic enzyme PGK via phosphorylation in Drosophila. Chen D, et al. mBio, 2024 Apr 10. PMID 38446061, Free PMC Article
  5. Novel Drosophila model for parkinsonism by targeting phosphoglycerate kinase. Shimizu J, et al. Neurochem Int, 2020 Oct. PMID 32758590

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of phase separation and antiviral activity of Cactin by glycolytic enzyme PGK via phosphorylation in Drosophila.
    Title: Regulation of phase separation and antiviral activity of Cactin by glycolytic enzyme PGK via phosphorylation in Drosophila.
  2. E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development.
    Title: E2F regulation of the Phosphoglycerate kinase gene is functionally important in Drosophila development.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ADP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphoglycerate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoglycerate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoglycerate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in canonical glycolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phosphoglycerate kinase
Names
CG3127-PA
CG3127-PB
CG3127-PC
CG3127-PD
CG3127-PE
Pgk-PA
Pgk-PB
Pgk-PC
Pgk-PD
Pgk-PE
lethal (2) 23AB3
phosphoglycerokinase
NP_001259956.1
NP_001259957.1
NP_001259958.1
NP_001259959.1
NP_476676.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2746880..2753068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273029.1 → NP_001259958.1  phosphoglycerate kinase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259958.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5XCG6, Q01604, Q3KN29, Q9VQF6
    UniProtKB/TrEMBL
    M9PCE0
    Conserved Domains (1) summary
    cl00198
    Location:1 → 414
    Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...

  2. NM_001273028.1 → NP_001259957.1  phosphoglycerate kinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259957.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5XCG6, Q01604, Q3KN29, Q9VQF6
    UniProtKB/TrEMBL
    M9PCE0
    Conserved Domains (1) summary
    cl00198
    Location:1 → 414
    Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...

  3. NM_001273027.1 → NP_001259956.1  phosphoglycerate kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259956.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5XCG6, Q01604, Q3KN29, Q9VQF6
    UniProtKB/TrEMBL
    M9PCE0
    Conserved Domains (1) summary
    cl00198
    Location:1 → 414
    Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...

  4. NM_001273030.1 → NP_001259959.1  phosphoglycerate kinase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259959.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5XCG6, Q01604, Q3KN29, Q9VQF6
    UniProtKB/TrEMBL
    M9PCE0
    Conserved Domains (1) summary
    cl00198
    Location:1 → 414
    Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...

  5. NM_057328.4 → NP_476676.1  phosphoglycerate kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476676.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5XCG6, Q01604, Q3KN29, Q9VQF6
    UniProtKB/TrEMBL
    M9PCE0
    Related
    FBpp0077419
    Conserved Domains (1) summary
    cl00198
    Location:1 → 414
    Phosphoglycerate_kinase; Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCE0 M9PCE0
Q01604.2 Q01604

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous