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exd2 exonuclease 3'-5' domain containing 2 [ Danio rerio (zebrafish) ]

Gene ID: 334455, updated on 12-Sep-2024

Summary

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Official Symbol
exd2provided by ZNC
Official Full Name
exonuclease 3'-5' domain containing 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6387
See related
Ensembl:ENSDARG00000016117 AllianceGenome:ZFIN:ZDB-GENE-030131-6387
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi72h12; wu:fi72h12; zgc:175195
Summary
Predicted to enable 3'-5' exonuclease activity. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human EXD2 (exonuclease 3'-5' domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See exd2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (51796668..51818675, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (51707633..51729650, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene si:ch211-168d23.3 Neighboring gene ornithine decarboxylase 1 Neighboring gene NUMB endocytic adaptor protein Neighboring gene FLVCR choline and putative heme transporter 2a Neighboring gene ergosterol biosynthesis 28 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Spatio-temporal mRNA tracking in the early zebrafish embryo. Holler K, et al. Nat Commun, 2021 Jun 7. PMID 34099733, Free PMC Article
  2. Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Mathiyalagan N, et al. Genes (Basel), 2019 Oct 31. PMID 31683705, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3'-5' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA 3'-5' DNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
exonuclease 3'-5' domain-containing protein 2
NP_001107878.1
XP_005169949.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114406.1 → NP_001107878.1  exonuclease 3'-5' domain-containing protein 2

    See identical proteins and their annotated locations for NP_001107878.1

    Status: PROVISIONAL

    Source sequence(s)
    BC159253
    UniProtKB/TrEMBL
    B0JZN3
    Related
    ENSDARP00000098875.1, ENSDART00000111389.4
    Conserved Domains (2) summary
    cd06141
    Location:83 → 263
    WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
    pfam14239
    Location:357 → 399
    RRXRR; RRXRR protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    51796668..51818675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169892.4 → XP_005169949.1  exonuclease 3'-5' domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BH75
    Conserved Domains (2) summary
    cd06141
    Location:83 → 258
    WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
    pfam14239
    Location:352 → 394
    RRXRR; RRXRR protein
Nucleotide Protein
Heading Accession and Version

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