heatr1 HEAT repeat containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: heatr1provided by ZNC
Official Full Name: HEAT repeat containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6378
See related: Ensembl:ENSDARG00000099742 AllianceGenome:ZFIN:ZDB-GENE-030131-6378
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: BAP28; fi69e12; flj10359; zC146F4.2; zgc:63510; BAP28-like; wu:fi69e12
Summary: Predicted to enable snoRNA binding activity. Acts upstream of or within maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of apoptotic process; and regulation of RNA stability. Predicted to be located in nucleolus. Predicted to be part of 90S preribosome; small-subunit processome; and t-UTP complex. Is expressed in eye; forebrain; immature eye; midbrain; and midbrain hindbrain boundary. Human ortholog(s) of this gene implicated in pancreatic ductal carcinoma. Orthologous to human HEATR1 (HEAT repeat containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (9619909..9700619, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (9582066..9663044, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The isolation of the bap28 mutation that leads to abnormalities in the brain starting at midsomitogenesis stages is reported.
Title: Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous system.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural precursor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nucleolus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of rRNA metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of RNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info
part_of t-UTP complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: HEAT repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199900.1 → NP_956194.1 HEAT repeat-containing protein 1

See identical proteins and their annotated locations for NP_956194.1

Status: PROVISIONAL

Source sequence(s)

BC055128

UniProtKB/Swiss-Prot

Q7SY48

Related

ENSDARP00000131597.1, ENSDART00000161063.2

Conserved Domains (3) summary

smart01036
Location:1860 → 2025

BP28CT; BP28CT (NUC211) domain

pfam12397
Location:240 → 356

U3snoRNP10; U3 small nucleolar RNA-associated protein 10

sd00044
Location:476 → 506

HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

9619909..9700619 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009306489.4 → XP_009304764.1 HEAT repeat-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M3B4F6

Conserved Domains (3) summary

smart01036
Location:1861 → 2026

BP28CT; BP28CT (NUC211) domain

pfam12397
Location:240 → 356

U3snoRNP10; U3 small nucleolar RNA-associated protein 10

sd00044
Location:476 → 506

HEAT; HEAT repeat [structural motif]