Eogt EGF-domain O-GlcNAc transferase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Eogtprovided by FlyBase
Official Full Name: EGF-domain O-GlcNAc transferaseprovided by FlyBase
Primary source: FLYBASE:FBgn0264672
Locus tag: Dmel_CG9867
See related: AllianceGenome:FB:FBgn0264672
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9867; Dmel\CG9867; eogt; EOGT
Summary: Enables protein O-acetylglucosaminyltransferase activity. Involved in larval chitin-based cuticle development and protein O-GlcNAcylation via threonine. Located in endoplasmic reticulum lumen. Is expressed in embryonic/larval garland cell; garland cell primordium; and organism. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 22E1-22E1; 2-6 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2381097..2383073)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2381097..2383073)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies provide evidence that EOGT plays important roles in drosophila, especially in its development.[review]
Title: EOGT and O-GlcNAc on secreted and membrane proteins.
Data suggest that Eogt knock-down in the wing leads to metabolic and signaling perturbations that increase cytosolic uracil levels, thereby causing wing blister formation.
Title: The EGF repeat-specific O-GlcNAc-transferase Eogt interacts with notch signaling and pyrimidine metabolism pathways in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein O-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein O-acetylglucosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein O-acetylglucosaminyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in larval chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein O-GlcNAcylation via threonine	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-GlcNAcylation via threonine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein O-linked glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein O-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: EGF-domain O-GlcNAc transferase

Names: CG9867-PA; CG9867-PB; EGF-domain specific O-GlcNAc transferase; Eogt-PA; Eogt-PB

NP_001259934.1

EC 2.4.-.-

EC 2.4.1.255

NP_608678.1

EC 2.4.-.-

EC 2.4.1.255

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

2381097..2383073

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_134834.3 → NP_608678.1 EGF-domain O-GlcNAc transferase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608678.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VQB7

UniProtKB/TrEMBL

M9PBV8

Related

FBpp0077447

Conserved Domains (1) summary

pfam04577
Location:232 → 454

DUF563; Protein of unknown function (DUF563)
NM_001273005.1 → NP_001259934.1 EGF-domain O-GlcNAc transferase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259934.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VQB7

UniProtKB/TrEMBL

M9PBV8

Conserved Domains (1) summary

pfam04577
Location:232 → 454

DUF563; Protein of unknown function (DUF563)