Rab5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab5provided by FlyBase
Primary source: FLYBASE:FBgn0014010
Locus tag: Dmel_CG3664
See related: AllianceGenome:FB:FBgn0014010
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAF51265; BAA88244; CG3664; Dm Rab5; Dmel\CG3664; DmRab5; drab5; dRab5; Drab5; DRab5; l(2)k08232; Rab; Rab 5; Rab-5; rab5; RAB5; RAB5a
Summary: Predicted to enable GTPase activity. Involved in several processes, including endocytosis; endosomal transport; and neuron projection morphogenesis. Located in cell cortex and early endosome. Is expressed in several structures, including central nervous system; circulatory system; extended germ band embryo; gut section; and imaginal disc. Used to study cancer and carcinoma. Orthologous to several human genes including RAB5B (RAB5B, member RAS oncogene family) and RAB5C (RAB5C, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 22E1-22E1; 2-6 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2359142..2365273, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2359142..2365273, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endocytosis mediated by an atypical CUBAM complex modulates slit diaphragm dynamics in nephrocytes.
Title: Endocytosis mediated by an atypical CUBAM complex modulates slit diaphragm dynamics in nephrocytes.
Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila.
Title: Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila.
The Rh1(also known as NinaE))-trafficking defect in PIP4K-depleted cells could be suppressed by downregulating Rab5 function or by selectively reconstituting PIP4K in the PI3P-enriched early endosomal compartment of photoreceptors
Title: Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis.
we discovered that the JNK signaling pathway operated between Rab5 and Dpp, because simultaneously inhibiting the JNK pathway and Rab5 in cyst cells prevented both dpp transcription and germline tumor growth
Title: Germline Proliferation Is Regulated by Somatic Endocytic Genes via JNK and BMP Signaling in Drosophila.
Our data reveal that the basolateral determinant Scribbled (Scrib) is required for PCV formation through optimizing BMP signaling. Scrib regulates BMP-type I receptor Thickveins (Tkv) localization at the basolateral region of PCV cells and subsequently facilitates Tkv internalization to Rab5 endosomes, where Tkv is active
Title: Scribbled Optimizes BMP Signaling through Its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis.
Ultrastructural analysis in Drosophila ooyctes revealed that loss of Rab5 leads to the accumulation of endocytic vesicles close to the plasma membrane.
Title: Three mechanisms control E-cadherin localization to the zonula adherens.
Two GTPases, Rab5 and dynamin, are required for both the increased endocytic activity and compartmentalized Ca2+ transients in the dendritic pruning of Drosophila sensory neurons.
Title: Local endocytosis triggers dendritic thinning and pruning in Drosophila sensory neurons.
Re-internalized Hedgehog is then regulated in a Rab5- and Rab4-dependent manner to ensure its long-range activity
Title: Endocytosis of Hedgehog through dispatched regulates long-range signaling.
Data shows that Rab5-defective cells are capable of indefinite proliferation, but are eliminated by cell competition.
Title: Cell competition may function either as tumour-suppressing or as tumour-stimulating factor in Drosophila.
Data indicate that dysfunction of Rab5 leads to cell-autonomous accumulation of a TNF homolog Eiger, and causes activation of Ras signaling.
Title: Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch receptor processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellularization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin-dependent endocytosis involved in vitellogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, amnioserosa morphology change	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome transport via multivesicular body sorting pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in multivesicular body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane to endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed
involved_in synaptic vesicle endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle endocytosis	TAS Traceable Author Statement more info	PubMed
involved_in synaptic vesicle endosomal processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle to endosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle to endosome fusion	TAS Traceable Author Statement more info	PubMed
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	NAS Non-traceable Author Statement more info	PubMed
located_in endocytic patch	IDA Inferred from Direct Assay more info	PubMed
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in multivesicular body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with presynaptic endosome	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	HDA more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Rab5

Names: CG3664-PA; CG3664-PB; CG3664-PC; CG3664-PD; CG3664-PE; CG3664-PF; CG3664-PG; CG3664-PH; CG3664-PI; Rab-protein 5; Rab5-PA; Rab5-PB; Rab5-PC; Rab5-PD; Rab5-PE; Rab5-PF; Rab5-PG; Rab5-PH; Rab5-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

2359142..2365273 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164477.3 → NP_722797.1 Rab5, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722797.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3I2

Related

FBpp0077473

Conserved Domains (1) summary

cd01860
Location:29 → 191

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
NM_078733.4 → NP_523457.1 Rab5, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523457.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3I2

Related

FBpp0077474

Conserved Domains (1) summary

cd01860
Location:29 → 191

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
NM_164476.2 → NP_722796.1 Rab5, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722796.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3I2

Related

FBpp0077470

Conserved Domains (1) summary

cd01860
Location:29 → 191

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
NM_164479.2 → NP_722799.1 Rab5, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722799.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3I2

Related

FBpp0077471

Conserved Domains (1) summary

cd01860
Location:29 → 191

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
NM_001272997.1 → NP_001259926.1 Rab5, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259926.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3I2

Conserved Domains (1) summary

cd01860
Location:29 → 191

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
NM_164478.2 → NP_722798.1 Rab5, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722798.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3I2

Related

FBpp0077472

Conserved Domains (1) summary

cd01860
Location:29 → 191

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
NM_001272996.1 → NP_001259925.1 Rab5, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259925.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3I2

Conserved Domains (1) summary

cd01860
Location:29 → 191

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
NM_164475.2 → NP_722795.1 Rab5, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722795.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3I2

Related

FBpp0077475

Conserved Domains (1) summary

cd01860
Location:29 → 191

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
NM_001272998.1 → NP_001259927.1 Rab5, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259927.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3I2

Conserved Domains (1) summary

cd01860
Location:29 → 191

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion