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Uch Ubiquitin carboxy-terminal hydrolase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33397, updated on 2-Nov-2024

Summary

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Official Symbol
Uchprovided by FlyBase
Official Full Name
Ubiquitin carboxy-terminal hydrolaseprovided by FlyBase
Primary source
FLYBASE:FBgn0010288
Locus tag
Dmel_CG4265
See related
AllianceGenome:FB:FBgn0010288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg4265; CG4265; Dmel\CG4265; dUch; dUCH; P35122; UBL; uch; UCH; uch-D; Uch-D; UCH-D; UCH-D19; UCH-L1; Uchl; Uchl1; UCHL1
Summary
Enables cysteine-type deubiquitinase activity. Involved in positive regulation of glycolytic process. Predicted to be active in cytoplasm. Is expressed in adult head; nurse cell; oocyte; organism; and spermatocyte. Used to study Parkinson's disease and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; hereditary spastic paraplegia 79A; and hereditary spastic paraplegia 79B. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Uch in Genome Data Viewer
Location:
22D4-22D4; 2-5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2212738..2214211, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2212738..2214211, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene daedalus Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Production of polyclonal anti-dUCH (Drosophila ubiquitin carboxyl-terminal hydrolase) antibodies. Tram NT, et al. Monoclon Antib Immunodiagn Immunother, 2013 Apr. PMID 23607345
  2. Crucial roles of UCH-L1 on insulin-producing cells and carbohydrate metabolism in Drosophila melanogaster model. Linh DM, et al. Exp Cell Res, 2022 Oct 15. PMID 35985499
  3. Cloning and analysis of expression of a ubiquitin carboxyl terminal hydrolase expressed during oogenesis in Drosophila melanogaster. Zhang N, et al. Dev Biol, 1993 May. PMID 7683284
  4. Therapeutic Potential of Polyscias fruticosa (L.) Harms Leaf Extract for Parkinson's Disease Treatment by Drosophila melanogaster Model. Ly HT, et al. Oxid Med Cell Longev, 2022. PMID 35633880, Free PMC Article
  5. Curcumin Effectively Rescued Parkinson's Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown. Nguyen TT, et al. Oxid Med Cell Longev, 2018. PMID 30057672, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health by Drosophila Model.
    Title: Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health by Drosophila Model.
  2. Targeting UCH in Drosophila melanogaster as a model for Parkinson's disease.
    Title: Targeting UCH in Drosophila melanogaster as a model for Parkinson's disease.
  3. Results suggest that UCH knockdown in drosophila is a promising model for studying the pathogenesis and epidemiology of Parkinson's disease. It shows degeneration of dopaminergic neurons followed by a shortage of dopamine on the brain and locomotor dysfunction.
    Title: Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson's Disease.
  4. These results indicate that the overexpression of dUCH impairs R7 photoreceptor cell differentiation by down-regulating the MAPK pathway.
    Title: Overexpression of ubiquitin carboxyl terminal hydrolase impairs multiple pathways during eye development in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of glycolytic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxy-terminal hydrolase
Names
CG4265-PA
CG4265-PB
CG4265-PC
Uch-PA
Uch-PB
Uch-PC
ubiquitin C-terminal hydrolase
ubiquitin carboxyl terminal hydrolase
ubiquitin carboxyterminal hydrolase
NP_001188681.1
NP_001259915.1
NP_476940.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2212738..2214211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057592.4 → NP_476940.1  ubiquitin carboxy-terminal hydrolase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476940.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35122, Q4PIX7, Q9TWA0, Q9V417
    UniProtKB/TrEMBL
    M9MRD0
    Related
    FBpp0077516
    Conserved Domains (1) summary
    cd09616
    Location:4 → 222
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

  2. NM_001272986.1 → NP_001259915.1  ubiquitin carboxy-terminal hydrolase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259915.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PE40
    Conserved Domains (1) summary
    cd09616
    Location:4 → 219
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

  3. NM_001201752.2 → NP_001188681.1  ubiquitin carboxy-terminal hydrolase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188681.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35122, Q4PIX7, Q9TWA0, Q9V417
    UniProtKB/TrEMBL
    M9MRD0
    Conserved Domains (1) summary
    cd09616
    Location:4 → 222
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MRD0 M9MRD0
M9PE40 M9PE40
P35122.2 P35122

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