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A4gnt alpha-1,4-N-acetylglucosaminyltransferase [ Mus musculus (house mouse) ]

Gene ID: 333424, updated on 2-Nov-2024

Summary

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Official Symbol
A4gntprovided by MGI
Official Full Name
alpha-1,4-N-acetylglucosaminyltransferaseprovided by MGI
Primary source
MGI:MGI:2143261
See related
Ensembl:ENSMUSG00000037953 AllianceGenome:MGI:2143261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm798; Alpha4gnt
Summary
This gene encodes a protein from the glycosyltransferase 32 family. The encoded enzyme catalyzes the transfer of N-acetylglucosamine to alpha-1,4-linked beta-galactose residues. This enzyme is required for type III mucin synthesis and it is largely associated with the Golgi apparatus membrane. The encoded protein appears to be expressed in adenocarcinoma cells of pancreatic, biliary tract and gastric cancers.[provided by RefSeq, Jan 2010]
Expression
Biased expression in stomach adult (RPKM 13.0), duodenum adult (RPKM 7.6) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See A4gnt in Genome Data Viewer
Location:
9 E3.3; 9 51.91 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (99473233..99504420)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (99591179..99622367)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25026 Neighboring gene NME/NM23 family member 9 Neighboring gene armadillo repeat containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E6796 Neighboring gene debranching RNA lariats 1 Neighboring gene DAZ interacting protein 1-like Neighboring gene claudin 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice. Iida M, et al. Sci Rep, 2021 Jul 1. PMID 34210998, Free PMC Article
  2. Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda. Kawakubo M, et al. J Histochem Cytochem, 2019 Oct. PMID 31246144, Free PMC Article
  3. Essential role of gastric gland mucin in preventing gastric cancer in mice. Karasawa F, et al. J Clin Invest, 2012 Mar. PMID 22307328, Free PMC Article
  4. Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk. Zheng Z, et al. Helicobacter, 2009 Oct. PMID 19751437, Free PMC Article
  5. Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin. Nakayama J, et al. Proc Natl Acad Sci U S A, 1999 Aug 3. PMID 10430883, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A4gnt(-/-) mice show complete lack of alphaGlcNAc expression in gastric gland mucin
    Title: Essential role of gastric gland mucin in preventing gastric cancer in mice.
  2. This publication contains functional information for the human homolog of mouse A4gnt.
    Title: Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin.
  3. This publication contains functional information for the human homolog of mouse A4gnt.
    Title: Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
alpha-1,4-N-acetylglucosaminyltransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077424.2 → NP_001070892.1  alpha-1,4-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_001070892.1

    Status: REVIEWED

    Source sequence(s)
    AC157949, AK136425
    Consensus CDS
    CCDS40740.1
    UniProtKB/Swiss-Prot
    Q14BT6
    Related
    ENSMUSP00000045629.8, ENSMUST00000042553.8
    Conserved Domains (2) summary
    pfam04488
    Location:65 → 183
    Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
    pfam04572
    Location:202 → 324
    Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    99473233..99504420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511246.5 → XP_006511309.1  alpha-1,4-N-acetylglucosaminyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006511309.1

    UniProtKB/Swiss-Prot
    Q14BT6
    Conserved Domains (2) summary
    pfam04488
    Location:65 → 183
    Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
    pfam04572
    Location:202 → 324
    Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

  2. XM_006511244.5 → XP_006511307.3  alpha-1,4-N-acetylglucosaminyltransferase isoform X1

    Conserved Domains (2) summary
    pfam04488
    Location:130 → 248
    Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
    pfam04572
    Location:267 → 389
    Gb3_synth; Alpha 1,4-glycosyltransferase conserved region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14BT6.1 GenPept UniProtKB/Swiss-Prot:Q14BT6

Gene LinkOut

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