Tfap2e transcription factor AP-2, epsilon [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tfap2eprovided by MGI
Official Full Name: transcription factor AP-2, epsilonprovided by MGI
Primary source: MGI:MGI:2679630
See related: Ensembl:ENSMUSG00000042477 AllianceGenome:MGI:2679630
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AP-2e; Tcfap2e
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including brain; early conceptus; neural ectoderm; ovary; and vomeronasal organ. Orthologous to human TFAP2E (transcription factor AP-2 epsilon). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 6.2), CNS E11.5 (RPKM 1.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 60.91 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (126609796..126630062, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (126716003..126736269, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factor activating enhancer-binding protein 2epsilon (AP2epsilon) modulates phenotypic plasticity and progression of malignant melanoma.
Title: Transcription factor activating enhancer-binding protein 2ε (AP2ε) modulates phenotypic plasticity and progression of malignant melanoma.
work suggests that AP-2epsilon, which is expressed in late phases of differentiation, is not needed to initiate the apical-basal differentiation dichotomy but for maintaining the basal VSNs' identity. In AP-2epsilon mutants we observed a large number of cells that entered the basal program can express apical genes, our data suggest that differentiated VSNs of mice retain a notable level of plasticity.
Title: The transcription factor Tfap2e/AP-2ε plays a pivotal role in maintaining the identity of basal vomeronasal sensory neurons.
We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 expression and activity.
Title: Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development.
Data demonstrate that transcription factor AP-2epsilon is required for olfactory bulb development, specifically the establishment of appropriate neuronal lamination.
Title: Disorganized olfactory bulb lamination in mice deficient for transcription factor AP-2epsilon.
cloning and characterization; AP-2 epsilon is expressed most prominently in the mitral cell layer of the developing olfactory bulb; it is able to activate transcription in a binding site-dependent manner
Title: Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb.
AP-2 epsilon is important for the development of the olfactory system.
Title: Identification and embryonic expression of a new AP-2 transcription factor, AP-2 epsilon.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI505200 (e-PCR)
- UniSTS:159291

Tcfap2e (e-PCR), detects polymorphism
- UniSTS:497490

NoName (e-PCR)
- UniSTS:491947

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: transcription factor AP-2-epsilon

Names: AP2-epsilon; activating enhancer-binding protein 2-epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.