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nAChRbeta3 nicotinic Acetylcholine Receptor beta3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33228, updated on 18-Sep-2024

Summary

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Official Symbol
nAChRbeta3provided by FlyBase
Official Full Name
nicotinic Acetylcholine Receptor beta3provided by FlyBase
Primary source
FLYBASE:FBgn0031261
Locus tag
Dmel_CG11822
See related
AllianceGenome:FB:FBgn0031261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11822; CT33131; Dbeta3; Dmel\CG11822; nAChR; nAChR-beta21C; nAChRbeta2; nAcR-21Beta; nAcRbeta-21C
Summary
Predicted to enable neurotransmitter receptor activity. Predicted to be involved in several processes, including cholinergic synaptic transmission; ion transmembrane transport; and regulation of membrane potential. Predicted to be located in postsynaptic membrane. Predicted to be active in neuron projection and synapse. Predicted to be integral component of plasma membrane. Is expressed in adult head; dorsal closure embryo; embryonic/larval plasmatocyte; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy; autosomal dominant nocturnal frontal lobe epilepsy 3; congenital myasthenic syndrome 1A; congenital myasthenic syndrome 1B; and lung cancer. Orthologous to several human genes including CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See nAChRbeta3 in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (545129..547096)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (545129..547096)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lesswright Neighboring gene Signal peptide peptidase Neighboring gene Ets at 21C Neighboring gene reduced mechanoreceptor potential A Neighboring gene uncharacterized nascent polypeptide-associated complex beta subunit Neighboring gene Translocator protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Host-cell specific effects of the nicotinic acetylcholine receptor chaperone RIC-3 revealed by a comparison of human and Drosophila RIC-3 homologues. Lansdell SJ, et al. J Neurochem, 2008 Jun. PMID 18208544
  2. Novel putative nicotinic acetylcholine receptor subunit genes, Dalpha5, Dalpha6 and Dalpha7, in Drosophila melanogaster identify a new and highly conserved target of adenosine deaminase acting on RNA-mediated A-to-I pre-mRNA editing. Grauso M, et al. Genetics, 2002 Apr. PMID 11973307, Free PMC Article
  3. Evidence for a diverse Cys-loop ligand-gated ion channel superfamily in early bilateria. Dent JA. J Mol Evol, 2006 May. PMID 16586016
  4. Drosophila signal peptide peptidase is an essential protease for larval development. Casso DJ, et al. Genetics, 2005 May. PMID 15716490, Free PMC Article
  5. Effects of nicotinic acetylcholine receptor subunit deletion mutants on insecticide susceptibility and fitness in Drosophila melanogaster. Zhang YC, et al. Pest Manag Sci, 2022 Aug. PMID 35576366

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, cholinergic ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nicotinic acetylcholine receptor beta3
Names
CG11822-PA
Dbeta3
nAChRbeta3-PA
nicotinic acetylcholine receptor beta 21C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    545129..547096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080359.4 → NP_525098.1  nicotinic acetylcholine receptor beta3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525098.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPQ8
    Related
    FBpp0077724
    Conserved Domains (3) summary
    TIGR00860
    Location:39 → 437
    LIC; Cation transporter family protein
    pfam02931
    Location:52 → 247
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:255 → 434
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95R44 Q95R44
Q9VPQ8 Q9VPQ8

Gene LinkOut

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