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Cyp6v1 Cytochrome P450 6v1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33056, updated on 18-Sep-2024

Summary

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Official Symbol
Cyp6v1provided by FlyBase
Official Full Name
Cytochrome P450 6v1provided by FlyBase
Primary source
FLYBASE:FBgn0031126
Locus tag
Dmel_CG1829
See related
AllianceGenome:FB:FBgn0031126
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6v1; CG1829; Dmel\CG1829
Summary
Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. Predicted to be involved in insecticide catabolic process and response to DDT. Is expressed in adult head; gonad; organism; and ring gland. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Cyp6v1 in Genome Data Viewer
Location:
19E1-19E1; 1-65 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20657122..20661425)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20528149..20532452)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Runt related A Neighboring gene antisense RNA:CR45466 Neighboring gene uncharacterized protein Neighboring gene hydra

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation. Schroeder MD, et al. Development, 2011 Jul. PMID 21693522, Free PMC Article
  2. Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation. Meiklejohn CD, et al. PLoS Biol, 2011 Aug. PMID 21857805, Free PMC Article
  3. Large clusters of co-expressed genes in the Drosophila genome. Boutanaev AM, et al. Nature, 2002 Dec 12. PMID 12478293
  4. CORECLUST: identification of the conserved CRM grammar together with prediction of gene regulation. Nikulova AA, et al. Nucleic Acids Res, 2012 Jul. PMID 22422836, Free PMC Article
  5. Comparative CYP-omic analysis between the DDT-susceptible and -resistant Drosophila melanogaster strains 91-C and 91-R. Seong KM, et al. Pest Manag Sci, 2018 Nov. PMID 29656515

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in insecticide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to DDT IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome P450 6v1
Names
CG1829-PA
CG1829-PB
CG1829-PC
Cyp6v1-PA
Cyp6v1-PB
Cyp6v1-PC
cytochrome P450
NP_001285499.1
NP_001285500.1
NP_608403.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    20657122..20661425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298570.1 → NP_001285499.1  cytochrome P450 6v1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285499.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9UNF2, Q9VRB3
    UniProtKB/TrEMBL
    X2JGA6
    Conserved Domains (1) summary
    cl12078
    Location:59 → 517
    p450; Cytochrome P450

  2. NM_134559.3 → NP_608403.1  cytochrome P450 6v1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608403.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9UNF2, Q9VRB3
    UniProtKB/TrEMBL
    X2JGA6
    Related
    FBpp0076968
    Conserved Domains (1) summary
    cl12078
    Location:59 → 517
    p450; Cytochrome P450

  3. NM_001298571.1 → NP_001285500.1  cytochrome P450 6v1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285500.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9UNF2, Q9VRB3
    UniProtKB/TrEMBL
    X2JGA6
    Conserved Domains (1) summary
    cl12078
    Location:59 → 517
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VRB3.1 Q9VRB3
X2JGA6 X2JGA6

Gene LinkOut

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