Ifnl2 interferon lambda 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifnl2provided by MGI
Official Full Name: interferon lambda 2provided by MGI
Primary source: MGI:MGI:3647279
See related: Ensembl:ENSMUSG00000059128 AllianceGenome:MGI:3647279
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il28a; IL-28A; If1ia1; EG330496
Summary: Predicted to enable interleukin-28 receptor binding activity. Involved in defense response to virus and mucosal immune response. Predicted to be located in extracellular region. Predicted to be part of interleukin-28 receptor complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; cryoglobulinemia; dengue hemorrhagic fever; hepatitis C; and liver disease (multiple). Orthologous to several human genes including IFNL2 (interferon lambda 2) and IFNL3 (interferon lambda 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7 A3; 7 16.8 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28208209..28209957, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28508784..28510532, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin 28A aggravates Con A-induced acute liver injury by promoting the recruitment of M1 macrophages.
Title: Interleukin 28A aggravates Con A-induced acute liver injury by promoting the recruitment of M1 macrophages.
IFN-lambda Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa.
Title: IFN-λ Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa.
Results support the idea of an exclusive role for known type III interferon cytokines in signaling via IFNLR to mediate antiviral effects at mucosal surfaces. These findings emphasize the importance of type III interferons in regulation of a variety of viral pathogens and provide important genetic evidence to support our understanding of the ligand-receptor interactions in this pathway.
Title: Disruption of Type III Interferon (IFN) Genes Ifnl2 and Ifnl3 Recapitulates Loss of the Type III IFN Receptor in the Mucosal Antiviral Response.
The authors show that processing of norovirus NS1/2 yields NS1, an unconventionally secreted viral protein that is central for IFN-lambda resistance. Murine norovirus infection globally suppresses intestinal IFN-lambda responses, which is attributable to secreted NS1.
Title: A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis.
Fetuses lacking IFN-lambda signaling had increased Zika virus replication in the placenta, and treatment of pregnant mice with IFN-lambda2 reduced ZIKV infection.
Title: Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero.
IFN-lambda2 and its receptor may become targets of anti-cancer therapy.
Title: Interferon lambda 2 promotes mammary tumor metastasis via angiogenesis extension and stimulation of cancer cell migration.
IL28 controls proliferation of IECs in mice with colitis and accelerates mucosal healing by activating STAT1.
Title: Activation of Epithelial Signal Transducer and Activator of Transcription 1 by Interleukin 28 Controls Mucosal Healing in Mice With Colitis and Is Increased in Mucosa of Patients With Inflammatory Bowel Disease.
IL-28A is capable of exacerbating a T-cell-mediated autoimmune disease.
Title: Interleukin-28A enhances autoimmune disease in a retinal autoimmunity model.
Data indicate that rotavirus infection induces production of interferon-lambda (IFN-lambda) and interleukin 22 (IL-22) by intestinal epithelial cells.
Title: Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.
IL-28A exerts its antiinflammatory effect by restricting recruitment of IL-1b-expressing neutrophils
Title: IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables interleukin-28 receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mucosal immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of interleukin-28 receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon lambda-2

Names: IFN-lambda-2; IFN-lambda2; interferon 1ia1; interferon-lambda2; interleukin-28A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.