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Far2 fatty acyl CoA reductase 2 [ Mus musculus (house mouse) ]

Gene ID: 330450, updated on 18-Jun-2024

Summary

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Official Symbol
Far2provided by MGI
Official Full Name
fatty acyl CoA reductase 2provided by MGI
Primary source
MGI:MGI:2687035
See related
Ensembl:ENSMUSG00000030303 AllianceGenome:MGI:2687035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlstd1; A230046P18
Summary
Enables fatty-acyl-CoA reductase (alcohol-forming) activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to act upstream of or within wax biosynthetic process. Located in peroxisome. Is expressed in alveolar sulcus; anterior naris; brain; ovary; and skin. Used to study alopecia. Orthologous to human FAR2 (fatty acyl-CoA reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 8.2), CNS E18 (RPKM 5.5) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Far2 in Genome Data Viewer
Location:
6 G3; 6 78.49 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (147948914..148084256)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148047416..148182758)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700049E15 gene Neighboring gene predicted gene 15762 Neighboring gene STARR-seq mESC enhancer starr_17826 Neighboring gene STARR-seq mESC enhancer starr_17827 Neighboring gene fatty acyl CoA reductase 2, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_17828 Neighboring gene STARR-seq mESC enhancer starr_17829 Neighboring gene STARR-seq mESC enhancer starr_17830 Neighboring gene RIKEN cDNA 4732416N19 gene Neighboring gene STARR-positive B cell enhancer ABC_E540 Neighboring gene STARR-positive B cell enhancer ABC_E3694 Neighboring gene ERGIC and golgi 2 Neighboring gene predicted gene, 52483 Neighboring gene transmembrane and tetratricopeptide repeat containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Formation of fatty alcohols-components of meibum lipids-by the fatty acyl-CoA reductase FAR2 is essential for dry eye prevention. Otsuka K, et al. FASEB J, 2022 Apr. PMID 35238077
  2. Detection and Classification of Novel Renal Histologic Phenotypes Using Deep Neural Networks. Sheehan S, et al. Am J Pathol, 2019 Sep. PMID 31220455, Free PMC Article
  3. Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia. Sundberg JP, et al. PLoS One, 2018. PMID 30372477, Free PMC Article
  4. Automatic glomerular identification and quantification of histological phenotypes using image analysis and machine learning. Sheehan SM, et al. Am J Physiol Renal Physiol, 2018 Dec 1. PMID 30256126, Free PMC Article
  5. Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate gene. Noordmans GA, et al. J Am Soc Nephrol, 2013 Dec. PMID 24009241, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Formation of fatty alcohols-components of meibum lipids-by the fatty acyl-CoA reductase FAR2 is essential for dry eye prevention.
    Title: Formation of fatty alcohols-components of meibum lipids-by the fatty acyl-CoA reductase FAR2 is essential for dry eye prevention.
  2. Results indicate fatty acyl CoA reductase 2 FAR2's role in the development of mesangial matrix expansion and chronic kidney disease.
    Title: FAR2 is associated with kidney disease in mice and humans.
  3. Far2 null mice provide further support for a central role for chronic sebadenitis in the development of a number of cicatricial alopecias. The Meibomian and clitoral glands (modified sebaceous glands) showed ducts dilated to various degrees that were associated with mild changes in the sebocytes as seen in the truncal skin.
    Title: Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia.
  4. Mouse strains with mesangial matrix expansion contain a 9-bp sequence in the 5' untranslated region of Far2 that is absent in most of the strains without it.
    Title: Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate gene.
  5. wax monoester synthesis in mammals involves a two step biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax synthase enzymes
    Title: Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family.
  6. fatty alcohol synthesis in mammals is accomplished by two fatty acyl-CoA reductase isozymes that are expressed at high levels in tissues known to synthesize wax monoesters and ether lipids
    Title: Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC67167

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alcohol-forming long-chain fatty acyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within wax biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fatty acyl-CoA reductase 2
Names
male sterility domain-containing protein 1
NP_001334445.1
NP_848912.1
XP_006507133.1
XP_036022150.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347516.1 → NP_001334445.1  fatty acyl-CoA reductase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK137298, AW048109, BC055759
    Consensus CDS
    CCDS85188.1
    UniProtKB/Swiss-Prot
    B2KFC6, Q3TTT7, Q7TNT2, Q8BH72, Q8CAK7
    Related
    ENSMUSP00000032443.8, ENSMUST00000032443.14
    Conserved Domains (2) summary
    cd05236
    Location:11 → 315
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein

  2. NM_178797.4 → NP_848912.1  fatty acyl-CoA reductase 2 isoform 2

    See identical proteins and their annotated locations for NP_848912.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences cause a translation frameshift and result in an isoform (2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK043388, AK043589
    Consensus CDS
    CCDS39718.1
    UniProtKB/Swiss-Prot
    Q7TNT2
    Related
    ENSMUSP00000107234.4, ENSMUST00000111607.4
    Conserved Domains (3) summary
    cd05236
    Location:11 → 315
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    PLN02996
    Location:7 → 447
    PLN02996; fatty acyl-CoA reductase
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    147948914..148084256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507070.5 → XP_006507133.1  fatty acyl-CoA reductase 2 isoform X1

    See identical proteins and their annotated locations for XP_006507133.1

    UniProtKB/Swiss-Prot
    B2KFC6, Q3TTT7, Q7TNT2, Q8BH72, Q8CAK7
    Conserved Domains (2) summary
    cd05236
    Location:11 → 315
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein

  2. XM_036166257.1 → XP_036022150.1  fatty acyl-CoA reductase 2 isoform X1

    UniProtKB/Swiss-Prot
    B2KFC6, Q3TTT7, Q7TNT2, Q8BH72, Q8CAK7
    Conserved Domains (2) summary
    cd05236
    Location:11 → 315
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    pfam03015
    Location:357 → 447
    Sterile; Male sterility protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNT2.1 GenPept UniProtKB/Swiss-Prot:Q7TNT2

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