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B4galnt3 beta-1,4-N-acetyl-galactosaminyl transferase 3 [ Mus musculus (house mouse) ]

Gene ID: 330406, updated on 28-Oct-2024

Summary

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Official Symbol
B4galnt3provided by MGI
Official Full Name
beta-1,4-N-acetyl-galactosaminyl transferase 3provided by MGI
Primary source
MGI:MGI:3041155
See related
Ensembl:ENSMUSG00000041372 AllianceGenome:MGI:3041155
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B4GalNAcT3; C330047A21
Summary
Predicted to enable acetylgalactosaminyltransferase activity. Predicted to be involved in chondroitin sulfate biosynthetic process. Predicted to be located in Golgi apparatus. Orthologous to human B4GALNT3 (beta-1,4-N-acetyl-galactosaminyltransferase 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in colon adult (RPKM 15.3), kidney adult (RPKM 10.3) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See B4galnt3 in Genome Data Viewer
Location:
6 F1; 6 56.94 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (120177714..120271879, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (120200753..120294917, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr6:119988697-119988998 Neighboring gene STARR-positive B cell enhancer ABC_E1708 Neighboring gene microRNA 706 Neighboring gene STARR-positive B cell enhancer ABC_E8832 Neighboring gene STARR-positive B cell enhancer ABC_E11333 Neighboring gene STARR-positive B cell enhancer mm9_chr6:120061967-120062268 Neighboring gene STARR-positive B cell enhancer mm9_chr6:120062467-120062768 Neighboring gene STARR-seq mESC enhancer starr_17160 Neighboring gene ninjurin 2 Neighboring gene STARR-positive B cell enhancer ABC_E2801 Neighboring gene STARR-positive B cell enhancer ABC_E2802 Neighboring gene STARR-positive B cell enhancer ABC_E10405 Neighboring gene predicted gene, 25327 Neighboring gene STARR-seq mESC enhancer starr_17164 Neighboring gene STARR-positive B cell enhancer ABC_E6477 Neighboring gene STARR-seq mESC enhancer starr_17178 Neighboring gene STARR-seq mESC enhancer starr_17179 Neighboring gene STARR-seq mESC enhancer starr_17181 Neighboring gene STARR-positive B cell enhancer ABC_E3675 Neighboring gene STARR-positive B cell enhancer ABC_E11334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120314296-120314483 Neighboring gene coiled-coil domain containing 77 Neighboring gene lysine demethylase 5A Neighboring gene predicted gene, 24592

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. B4GALNT3 regulates glycosylation of sclerostin and bone mass. Movérare-Skrtic S, et al. EBioMedicine, 2023 May. PMID 37023531, Free PMC Article
  2. GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating α-Klotho levels. Gergei I, et al. Hum Mol Genet, 2022 Mar 3. PMID 34542150, Free PMC Article
  3. Beta1,4-N-acetylgalactosaminyltransferase III enhances malignant phenotypes of colon cancer cells. Huang J, et al. Mol Cancer Res, 2007 Jun. PMID 17579116
  4. Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc. Sato T, et al. J Biol Chem, 2003 Nov 28. PMID 12966086
  5. Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4. Fiete D, et al. J Biol Chem, 2012 Aug 17. PMID 22722940, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4.
    Title: Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4.
  2. Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases beta1,4-N-acetylgalactosaminyl transferase 3 (beta4GalNAc-T3) and beta4GalNAc-T4.
    Title: Molecular basis for protein-specific transfer of N-acetylgalactosamine to N-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4.
  3. up-regulation of beta4GalNAc-T3 may play a critical role in promoting tumor malignanc
    Title: Beta1,4-N-acetylgalactosaminyltransferase III enhances malignant phenotypes of colon cancer cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylgalactosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chondroitin sulfate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
beta-1,4-N-acetylgalactosaminyltransferase 3
Names
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2
NGalNAc-T2
beta 1,4-N-acetylgalactosaminyltransferase-transferase 3
beta 1,4-N-acetylgalactosaminyltransferase-transferase-III
beta-1,4-N-acetylgalactosaminyltransferase III
beta4GalNAc-T3
beta4GalNAcT3
NP_942585.1
XP_006506379.1
XP_006506381.1
XP_011239697.1
XP_017177147.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198884.2 → NP_942585.1  beta-1,4-N-acetylgalactosaminyltransferase 3

    See identical proteins and their annotated locations for NP_942585.1

    Status: VALIDATED

    Source sequence(s)
    AC155720, AC156951
    Consensus CDS
    CCDS20480.1
    UniProtKB/Swiss-Prot
    Q6L8S8
    UniProtKB/TrEMBL
    A4QPE8
    Related
    ENSMUSP00000058253.8, ENSMUST00000057283.8
    Conserved Domains (2) summary
    pfam07691
    Location:143 → 277
    PA14; PA14 domain
    cl11394
    Location:776 → 972
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    120177714..120271879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506316.5 → XP_006506379.1  beta-1,4-N-acetylgalactosaminyltransferase 3 isoform X1

    UniProtKB/TrEMBL
    A0A1D5RMF7, A4QPE8
    Related
    ENSMUSP00000148759.2, ENSMUST00000212457.2
    Conserved Domains (2) summary
    smart00758
    Location:140 → 277
    PA14; domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins
    cl11394
    Location:654 → 971
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. XM_017321658.1 → XP_017177147.1  beta-1,4-N-acetylgalactosaminyltransferase 3 isoform X3

    UniProtKB/TrEMBL
    A4QPE8
    Conserved Domains (1) summary
    cl11394
    Location:365 → 682
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  3. XM_011241395.2 → XP_011239697.1  beta-1,4-N-acetylgalactosaminyltransferase 3 isoform X2

    UniProtKB/TrEMBL
    A4QPE8
    Conserved Domains (2) summary
    smart00758
    Location:117 → 254
    PA14; domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins
    cl11394
    Location:632 → 949
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  4. XM_006506318.5 → XP_006506381.1  beta-1,4-N-acetylgalactosaminyltransferase 3 isoform X4

    Conserved Domains (1) summary
    smart00758
    Location:140 → 277
    PA14; domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6L8S8.1 GenPept UniProtKB/Swiss-Prot:Q6L8S8

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