U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rab10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33025, updated on 4-Jul-2024

Summary

Go to the top of the page Help
Official Symbol
Rab10provided by FlyBase
Primary source
FLYBASE:FBgn0015789
Locus tag
Dmel_CG17060
See related
AllianceGenome:FB:FBgn0015789
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF50924; CG17060; Dmel\CG17060; DmRab10; DRab10; DRAB10; O15971; Rab-r10; rab10
Summary
Predicted to enable GTPase activity. Involved in several processes, including basal protein localization; growth of a germarium-derived egg chamber; and secretion by cell. Located in several cellular components, including basal part of cell; cell trailing edge; and lateral plasma membrane. Is expressed in several structures, including Bolwig organ; adult heart; embryonic/larval salivary gland; imaginal disc; and nervous system. Orthologous to human RAB10 (RAB10, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rab10 in Genome Data Viewer
Location:
19C1-19C1; 1-64 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20251338..20254691)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20122412..20125717)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Peritrophin A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Role for Rab10 in Methamphetamine-Induced Behavior. Vanderwerf SM, et al. PLoS One, 2015. PMID 26291453, Free PMC Article
  2. ESCargo: a regulatable fluorescent secretory cargo for diverse model organisms. Casler JC, et al. Mol Biol Cell, 2020 Dec 15. PMID 33112725, Free PMC Article
  3. A novel function for Rab1 and Rab11 during secretory granule maturation. Neuman SD, et al. J Cell Sci, 2021 Aug 1. PMID 34342349, Free PMC Article
  4. Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons. Fellgett A, et al. J Parkinsons Dis, 2021. PMID 34250948, Free PMC Article
  5. Drosophila Embryonic Hemocytes Produce Laminins to Strengthen Migratory Response. Sánchez-Sánchez BJ, et al. Cell Rep, 2017 Nov 7. PMID 29117553, Free PMC Article

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stratum is required for both apical and basolateral transport through stable expression of Rab10 and Rab35 in Drosophila photoreceptors.
    Title: Stratum is required for both apical and basolateral transport through stable expression of Rab10 and Rab35 in Drosophila photoreceptors.
  2. find that a Rab10-based secretion pathway promotes pericellular basement membranes protein accumulation and fibril formation
    Title: Rab10-Mediated Secretion Synergizes with Tissue Movement to Build a Polarized Basement Membrane Architecture for Organ Morphogenesis.
  3. identifed a mechanism for polarized basement membrane(BM)secretion in follicle cells; BM proteins are synthesized in a basal ER compartment and exported through Tango1-positive ER exit sites to basal Golgi clusters; Crag targets Rab10 to structures in the basal cytoplasm, where it restricts protein delivery to the basal surface
    Title: A Rab10-dependent mechanism for polarized basement membrane secretion during organ morphogenesis.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables myosin V binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rab protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in basal protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in basement membrane constituent secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in basolateral protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in growth of a germarium-derived egg chamber IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of basement membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in symbiont entry into host cell HMP PubMed 
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basal part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell trailing edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body HDA PubMed 
located_in recycling endosome HDA PubMed 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in secretory vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse HDA PubMed 
located_in vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Rab10
Names
CG17060-PA
Rab-protein 10
Rab10-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    20251338..20254691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078695.4 → NP_523419.1  Rab10 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523419.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O15971
    Related
    FBpp0077029
    Conserved Domains (1) summary
    cd01867
    Location:7 → 173
    Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15971 O15971

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous