Catsper4 cation channel, sperm associated 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Catsper4provided by MGI
Official Full Name: cation channel, sperm associated 4provided by MGI
Primary source: MGI:MGI:3043288
See related: Ensembl:ENSMUSG00000048003 AllianceGenome:MGI:3043288
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933412L05
Summary: Enables voltage-gated calcium channel activity. Acts upstream of or within several processes, including flagellated sperm motility; sodium ion transport; and sperm capacitation. Located in acrosomal vesicle and sperm principal piece. Part of CatSper complex. Orthologous to human CATSPER4 (cation channel sperm associated 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Restricted expression toward testis adult (RPKM 45.5) See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.5 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133939276..133954743, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (134211965..134227431, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that spinal cord injury doesn't significantly change the expression of CatSpers 4.
Title: CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model.
Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions.
Title: Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse.
Catsper4 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer.
Title: Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis.
CATSPER4 is a cation-channel protein and has role in acrosome reaction and male fertility
Title: Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-activated cation channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm capacitation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CatSper complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CatSper complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in sperm principal piece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm principal piece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cation channel sperm-associated protein 4

Names: cation channel of sperm 4; channel, sperm associated 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130030.1 → NP_001123502.1 cation channel sperm-associated protein 4 isoform 2

See identical proteins and their annotated locations for NP_001123502.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) is missing 2 contiguous internal coding exons compared to variant 1, however, it maintains the reading frame, and encodes a shorter isoform (2) that is lacking a 73 aa internal segment compared to isoform 1.

Source sequence(s)

AK077145, BY104668, CR513858, EU781511

Consensus CDS

CCDS51324.1

UniProtKB/TrEMBL

B3VNK5

Related

ENSMUSP00000131094.2, ENSMUST00000169381.8

Conserved Domains (2) summary

pfam00520
Location:126 → 216

Ion_trans; Ion transport protein

cl00567
Location:101 → 201

Colicin_V; Colicin V production protein
NM_177866.4 → NP_808534.1 cation channel sperm-associated protein 4 isoform 1

See identical proteins and their annotated locations for NP_808534.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK077145, BY104668, CR513858

Consensus CDS

CCDS18766.1

UniProtKB/Swiss-Prot

A2A9K6, Q8BVN3

Related

ENSMUSP00000051694.4, ENSMUST00000055892.10

Conserved Domains (1) summary

pfam00520
Location:81 → 289

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

133939276..133954743 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164199.1 → XP_036020092.1 cation channel sperm-associated protein 4 isoform X1

Conserved Domains (1) summary

pfam00520
Location:81 → 289

Ion_trans; Ion transport protein
XM_011250280.3 → XP_011248582.1 cation channel sperm-associated protein 4 isoform X2

Conserved Domains (1) summary

pfam00520
Location:81 → 243

Ion_trans; Ion transport protein