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COX6B Cytochrome c oxidase subunit 6B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32989, updated on 2-Nov-2024

Summary

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Official Symbol
COX6Bprovided by FlyBase
Official Full Name
Cytochrome c oxidase subunit 6Bprovided by FlyBase
Primary source
FLYBASE:FBgn0031066
Locus tag
Dmel_CG14235
See related
AllianceGenome:FB:FBgn0031066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CcoVIb; CG14235; CoVIb; Cox6b; COXG; Dmel\CG14235; Q8IQW2; vib; VIb
Summary
Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 7. Orthologous to several human genes including COX6B1 (cytochrome c oxidase subunit 6B1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See COX6B in Genome Data Viewer
Location:
18E5-18E5; 1-64 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19740537..19744335, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19634570..19638368, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Adaptor Protein complex 1/2, beta subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45501 Neighboring gene Ribonuclease P protein subunit p20 Neighboring gene parvin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Ren JC, et al. Biochem Biophys Res Commun, 2010 Oct 8. PMID 20833144, Free PMC Article
  2. Apple polyphenols extend the mean lifespan of Drosophila melanogaster. Peng C, et al. J Agric Food Chem, 2011 Mar 9. PMID 21319854
  3. Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Kemppainen KK, et al. Hum Mol Genet, 2014 Apr 15. PMID 24293544, Free PMC Article
  4. The misregulation of mitochondria-associated genes caused by GAGA-factor lack promotes autophagic germ cell death in Drosophila testes. Dorogova NV, et al. Genetica, 2023 Dec. PMID 37819589
  5. Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene. Porcelli D, et al. Mitochondrion, 2010 Aug. PMID 20388558

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 6B
Names
CG14235-PA
CG14235-PB
CG14235-PC
CG14235-PD
COX6B-PA
COX6B-PB
COX6B-PC
COX6B-PD
cytochrome c oxidase VIb
cytochrome c oxidase polypeptide VIb
cytochrome c oxidase subunit VIb
cytochrome c oxidase subunitVIb
subunit VIb

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19740537..19744335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167680.3 → NP_728296.1  cytochrome c oxidase subunit 6B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728296.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQW2
    Related
    FBpp0074585
    Conserved Domains (1) summary
    cd00926
    Location:3 → 76
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. NM_167678.3 → NP_728294.1  cytochrome c oxidase subunit 6B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728294.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWD1
    Related
    FBpp0074584
    Conserved Domains (1) summary
    cd00926
    Location:22 → 95
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  3. NM_001258838.2 → NP_001245767.1  cytochrome c oxidase subunit 6B, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245767.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQW2
    Conserved Domains (1) summary
    cd00926
    Location:3 → 76
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  4. NM_167679.3 → NP_728295.1  cytochrome c oxidase subunit 6B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728295.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQW2
    Related
    FBpp0074586
    Conserved Domains (1) summary
    cd00926
    Location:3 → 76
    Cyt_c_Oxidase_VIb; Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQW2 Q8IQW2
Q9VWD1 Q9VWD1

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