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Zw Zwischenferment [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32974, updated on 28-Oct-2024

Summary

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Official Symbol
Zwprovided by FlyBase
Official Full Name
Zwischenfermentprovided by FlyBase
Primary source
FLYBASE:FBgn0004057
Locus tag
Dmel_CG12529
See related
AllianceGenome:FB:FBgn0004057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12529; Dmel\CG12529; G-6-PD; G-6-pdh; G-6pd; G-6PD; G6-pd; G6-PD; g6pd; G6pd; G6PD; G6pdh; G6PDH; zw
Summary
Enables glucose-6-phosphate dehydrogenase activity. Involved in pentose-phosphate shunt, oxidative branch. Predicted to be active in cytosol. Is expressed in adult fat body and adult head. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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Location:
18D13-18D13; 1-63 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19667252..19672353)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19561285..19566386)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44512 Neighboring gene Ssu72 CTD phosphatase Neighboring gene eye transformer Neighboring gene domeless Neighboring gene Ubiquilin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of gene function: a comparison of enzyme activity levels in relation to gene dosage in diploids and triploids of Drosophila melanogaster. Lucchesi JC, et al. Biochem Genet, 1973 May. PMID 4197884
  2. Dosage Compensation in DROSOPHILA MELANOGASTER Triploids. II. Glucose-6-Phosphate Dehydrogenase Activity. Maroni G, et al. Genetics, 1973 Jun. PMID 17248620, Free PMC Article
  3. IN VIVO Function of Rare G6pd Variants from Natural Populations of DROSOPHILA MELANOGASTER. Eanes WF, et al. Genetics, 1986 Jul. PMID 17246336, Free PMC Article
  4. Coding sequence evolution. Kreitman M, et al. Curr Opin Genet Dev, 1999 Dec. PMID 10607619
  5. Amino acid polymorphism and rare electrophoretic variants of G6PD from natural populations of Drosophila melanogaster. Eanes WF, et al. Genetics, 1996 May. PMID 8722791, Free PMC Article

See all (256) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. glucose-6-phosphate dehydrogenase overexpression extends the life span of Drosophila melanogaster
    Title: Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables glucose-6-phosphate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose-6-phosphate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose-6-phosphate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose-6-phosphate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in NADP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose-phosphate shunt, oxidative branch IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zwischenferment
Names
CG12529-PA
CG12529-PB
CG12529-PC
Glucose-6-phosphate DH
Zw-PA
Zw-PB
Zw-PC
glucose 6-phosphate dehydrogenase
glucose-6-phosphate 1dehydrogenase
glucose-6-phosphate dehydrogenase
zwishenferment
NP_001285456.1
NP_523411.1
NP_728287.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19667252..19672353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078687.2 → NP_523411.1  zwischenferment, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523411.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7FNK0, P12646, Q27574, Q27872, Q27879, Q27881, Q9VWE2, Q9VWE3, X2JEF0
    Related
    FBpp0074517
    Conserved Domains (3) summary
    TIGR00871
    Location:35 → 498
    zwf; glucose-6-phosphate 1-dehydrogenase
    pfam00479
    Location:39 → 213
    G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
    pfam02781
    Location:216 → 508
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  2. NM_167676.2 → NP_728287.1  zwischenferment, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728287.1

    Status: REVIEWED

    Related
    FBpp0074518
    Conserved Domains (3) summary
    TIGR00871
    Location:13 → 476
    zwf; glucose-6-phosphate 1-dehydrogenase
    pfam00479
    Location:17 → 191
    G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
    pfam02781
    Location:194 → 486
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  3. NM_001298527.1 → NP_001285456.1  zwischenferment, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285456.1

    Status: REVIEWED

    Conserved Domains (3) summary
    TIGR00871
    Location:13 → 476
    zwf; glucose-6-phosphate 1-dehydrogenase
    pfam00479
    Location:17 → 191
    G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
    pfam02781
    Location:194 → 486
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12646.2 P12646
X2JEF0 X2JEF0

Gene LinkOut

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