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Tafa3 TAFA chemokine like family member 3 [ Mus musculus (house mouse) ]

Gene ID: 329731, updated on 2-Nov-2024

Summary

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Official Symbol
Tafa3provided by MGI
Official Full Name
TAFA chemokine like family member 3provided by MGI
Primary source
MGI:MGI:3046463
See related
Ensembl:ENSMUSG00000055865 AllianceGenome:MGI:3046463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sam3; Tafa-3; Fam19a3; 7530404M11Rik
Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis adult (RPKM 2.5), heart adult (RPKM 0.9) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Tafa3 in Genome Data Viewer
Location:
3 F2.2; 3 45.84 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104674721..104686854, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104767405..104779542, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24223 Neighboring gene STARR-positive B cell enhancer mm9_chr3:104518140-104518441 Neighboring gene STARR-seq mESC enhancer starr_08619 Neighboring gene predicted gene 6485 Neighboring gene STARR-seq mESC enhancer starr_08620 Neighboring gene protein phosphatase 1J Neighboring gene ras homolog family member C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency of a brain-specific chemokine-like molecule, SAM3, induces cardinal phenotypes of autism spectrum disorders in mice. Kim S, et al. Sci Rep, 2017 Nov 28. PMID 29184127, Free PMC Article
  2. FAM19A3, a novel secreted protein, modulates the microglia/macrophage polarization dynamics and ameliorates cerebral ischemia. Shao Y, et al. FEBS Lett, 2015 Feb 13. PMID 25595455
  3. Tafa-3 encoding for a secretory peptide is expressed in the mouse pars tuberalis and is affected by melatonin 1 receptor deficiency. Fischer C, et al. Gen Comp Endocrinol, 2012 May 15. PMID 22426341
  4. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. Tom Tang Y, et al. Genomics, 2004 Apr. PMID 15028294
  5. Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci. Lees-Murdock DJ, et al. Genomics, 2004 Jul. PMID 15203217

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data suggest that TAFA-3 is a signaling molecule from the hypophysial pars tuberalis.
    Title: Tafa-3 encoding for a secretory peptide is expressed in the mouse pars tuberalis and is affected by melatonin 1 receptor deficiency.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of microglial cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of microglial cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuroblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microglial cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of microglial cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of neuroblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
chemokine-like protein TAFA-3
Names
family with sequence similarity 19, member A3
protein FAM19A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183224.3 → NP_899047.1  chemokine-like protein TAFA-3 precursor

    See identical proteins and their annotated locations for NP_899047.1

    Status: REVIEWED

    Source sequence(s)
    AC171110, AK078681
    Consensus CDS
    CCDS51032.1
    UniProtKB/Swiss-Prot
    Q147Z7, Q7TPG6
    Related
    ENSMUSP00000123514.2, ENSMUST00000139783.2
    Conserved Domains (1) summary
    pfam12020
    Location:42 → 130
    TAFA; TAFA family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    104674721..104686854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163140.1 → XP_036019033.1  chemokine-like protein TAFA-3 isoform X1

    UniProtKB/Swiss-Prot
    Q147Z7, Q7TPG6
    Conserved Domains (1) summary
    pfam12020
    Location:42 → 130
    TAFA; TAFA family

  2. XM_017319626.3 → XP_017175115.1  chemokine-like protein TAFA-3 isoform X1

    UniProtKB/Swiss-Prot
    Q147Z7, Q7TPG6
    Conserved Domains (1) summary
    pfam12020
    Location:42 → 130
    TAFA; TAFA family

  3. XM_036163139.1 → XP_036019032.1  chemokine-like protein TAFA-3 isoform X2

    Conserved Domains (1) summary
    pfam12020
    Location:78 → 166
    TAFA; TAFA family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPG6.1 GenPept UniProtKB/Swiss-Prot:Q7TPG6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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