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Dcst2 DC-STAMP domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 329702, updated on 12-May-2024

Summary

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Official Symbol
Dcst2provided by MGI
Official Full Name
DC-STAMP domain containing 2provided by MGI
Primary source
MGI:MGI:2685606
See related
Ensembl:ENSMUSG00000109293 AllianceGenome:MGI:2685606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm760
Summary
Orthologous to human DCST2 (DC-STAMP domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 39.0) and mammary gland adult (RPKM 2.0) See more
Orthologs
human all
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Genomic context

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See Dcst2 in Genome Data Viewer
Location:
3 F1; 3 39.09 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89257724..89284950)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89350417..89377643)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ephrin A4 Neighboring gene ADAM metallopeptidase domain 15 Neighboring gene STARR-positive B cell enhancer ABC_E4553 Neighboring gene DC-STAMP domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_08235 Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene STARR-seq mESC enhancer starr_08237 Neighboring gene STARR-positive B cell enhancer ABC_E3446 Neighboring gene predicted gene 15417 Neighboring gene lens epithelial protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish. Noda T, et al. Commun Biol, 2022 Apr 7. PMID 35393517, Free PMC Article
  2. Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion. Inoue N, et al. Elife, 2021 Apr 19. PMID 33871360, Free PMC Article
  3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.
    Title: Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm-egg recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DC-STAMP domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370853.1 → NP_001357782.1  DC-STAMP domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS89657.1
    UniProtKB/Swiss-Prot
    A0A140LIJ0
    Related
    ENSMUSP00000146838.2, ENSMUST00000208216.2
    Conserved Domains (2) summary
    pfam07782
    Location:342 → 532
    DC_STAMP; DC-STAMP-like protein
    pfam12368
    Location:585 → 627
    Rhodanese_C; Rhodanase C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89257724..89284950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319855.1 → XP_017175344.1  DC-STAMP domain-containing protein 2 isoform X7

    Conserved Domains (2) summary
    pfam07782
    Location:218 → 408
    DC_STAMP; DC-STAMP-like protein
    pfam12368
    Location:461 → 503
    Rhodanese_C; Rhodanase C-terminal

  2. XM_017319854.3 → XP_017175343.1  DC-STAMP domain-containing protein 2 isoform X7

    Conserved Domains (2) summary
    pfam07782
    Location:218 → 408
    DC_STAMP; DC-STAMP-like protein
    pfam12368
    Location:461 → 503
    Rhodanese_C; Rhodanase C-terminal

  3. XM_030252652.2 → XP_030108512.1  DC-STAMP domain-containing protein 2 isoform X8

    Conserved Domains (2) summary
    pfam07782
    Location:158 → 348
    DC_STAMP; DC-STAMP-like protein
    pfam12368
    Location:401 → 443
    Rhodanese_C; Rhodanase C-terminal

  4. XM_017319851.2 → XP_017175340.1  DC-STAMP domain-containing protein 2 isoform X4

    Conserved Domains (2) summary
    pfam07782
    Location:342 → 476
    DC_STAMP; DC-STAMP-like protein
    pfam12368
    Location:529 → 571
    Rhodanese_C; Rhodanase C-terminal

  5. XM_017319849.2 → XP_017175338.1  DC-STAMP domain-containing protein 2 isoform X2

    Conserved Domains (2) summary
    pfam07782
    Location:320 → 510
    DC_STAMP; DC-STAMP-like protein
    pfam12368
    Location:563 → 605
    Rhodanese_C; Rhodanase C-terminal

  6. XM_017319852.3 → XP_017175341.1  DC-STAMP domain-containing protein 2 isoform X6

    Conserved Domains (2) summary
    pfam07782
    Location:254 → 444
    DC_STAMP; DC-STAMP-like protein
    pfam12368
    Location:497 → 539
    Rhodanese_C; Rhodanase C-terminal

  7. XM_006502511.4 → XP_006502574.1  DC-STAMP domain-containing protein 2 isoform X9

    See identical proteins and their annotated locations for XP_006502574.1

    Conserved Domains (1) summary
    pfam07782
    Location:342 → 438
    DC_STAMP; DC-STAMP-like protein

  8. XM_011240348.3 → XP_011238650.1  DC-STAMP domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011238650.1

    Conserved Domains (2) summary
    pfam07782
    Location:342 → 532
    DC_STAMP; DC-STAMP-like protein
    pfam12368
    Location:585 → 627
    Rhodanese_C; Rhodanase C-terminal

  9. XM_017319850.2 → XP_017175339.1  DC-STAMP domain-containing protein 2 isoform X3

    Conserved Domains (2) summary
    pfam07782
    Location:290 → 480
    DC_STAMP; DC-STAMP-like protein
    pfam12368
    Location:533 → 575
    Rhodanese_C; Rhodanase C-terminal

  10. XM_006502503.4 → XP_006502566.1  DC-STAMP domain-containing protein 2 isoform X5

    See identical proteins and their annotated locations for XP_006502566.1

    Conserved Domains (2) summary
    pfam07782
    Location:342 → 532
    DC_STAMP; DC-STAMP-like protein
    pfam12368
    Location:585 → 627
    Rhodanese_C; Rhodanase C-terminal

  11. XM_030252653.2 → XP_030108513.1  DC-STAMP domain-containing protein 2 isoform X10

    Conserved Domains (2) summary
    pfam07782
    Location:84 → 218
    DC_STAMP; DC-STAMP-like protein
    pfam12368
    Location:271 → 313
    Rhodanese_C; Rhodanase C-terminal

RNA

  1. XR_004941336.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A140LIJ0.1 GenPept UniProtKB/Swiss-Prot:A0A140LIJ0

Gene LinkOut

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Chemical Information
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