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CG14220 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32954, updated on 2-Nov-2024

Summary

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Official Symbol
CG14220provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031036
Locus tag
Dmel_CG14220
See related
AllianceGenome:FB:FBgn0031036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg14220; Dmel\CG14220; Sds3; SDS3
Summary
Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Part of Sin3-type complex. Orthologous to human SUDS3 (SDS3 homolog, SIN3A corepressor complex component). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG14220 in Genome Data Viewer
Location:
18D3-18D3; 1-63 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19599803..19601851, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19493836..19495884, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S10b Neighboring gene uncharacterized protein Neighboring gene tyler Neighboring gene shawn

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic Analysis of SIN3 Histone Modifying Complex Components During Development. Barnes VL, et al. Sci Rep, 2018 Nov 19. PMID 30451916, Free PMC Article
  2. The Drosophila ortholog of breast cancer metastasis suppressor gene, dBrms1, is critical for developmental timing through regulating ecdysone signaling. Song S, et al. Dev Biol, 2013 Aug 15. PMID 23707898
  3. Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. Spain MM, et al. J Biol Chem, 2010 Aug 27. PMID 20566628, Free PMC Article
  4. The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules. Zhang W, et al. J Mol Biol, 2016 Jul 17. PMID 27117189, Free PMC Article
  5. Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation. Larschan E, et al. PLoS Genet, 2012. PMID 22844249, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Sin3-type complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG14220-PA
CG14220-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19599803..19601851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258830.2 → NP_001245759.1  uncharacterized protein Dmel_CG14220, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245759.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS11, Q9VWG2
    Conserved Domains (1) summary
    pfam08598
    Location:58 → 171
    Sds3; Sds3-like

  2. NM_134481.2 → NP_608325.1  uncharacterized protein Dmel_CG14220, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608325.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS11, Q9VWG2
    Related
    FBpp0074537
    Conserved Domains (1) summary
    pfam08598
    Location:58 → 171
    Sds3; Sds3-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MS11 Q8MS11
Q9VWG2 Q9VWG2

Gene LinkOut

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