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Lgr6 leucine-rich repeat-containing G protein-coupled receptor 6 [ Mus musculus (house mouse) ]

Gene ID: 329252, updated on 28-Oct-2024

Summary

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Official Symbol
Lgr6provided by MGI
Official Full Name
leucine-rich repeat-containing G protein-coupled receptor 6provided by MGI
Primary source
MGI:MGI:2441805
See related
Ensembl:ENSMUSG00000042793 AllianceGenome:MGI:2441805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D830026M09; A530037C04Rik
Summary
Predicted to enable G protein-coupled receptor activity and protein-hormone receptor activity. Acts upstream of or within bone regeneration and cell population proliferation. Predicted to be located in vesicle. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including cochlea; jaw; renal cortex; skin; and telencephalon. Orthologous to human LGR6 (leucine rich repeat containing G protein-coupled receptor 6). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in ovary adult (RPKM 9.3), heart adult (RPKM 5.7) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Lgr6 in Genome Data Viewer
Location:
1 E4; 1 58.24 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134911038..135033112, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134983300..135105374, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 12B Neighboring gene predicted gene, 51748 Neighboring gene STARR-positive B cell enhancer ABC_E1231 Neighboring gene microRNA 5104b Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene STARR-seq mESC enhancer starr_02346 Neighboring gene STARR-seq mESC enhancer starr_02347 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:137029652-137029867 Neighboring gene STARR-positive B cell enhancer ABC_E9480 Neighboring gene protein tyrosine phosphatase receptor type V Neighboring gene protein tyrosine phosphatase, non-receptor type 7 Neighboring gene ADP-ribosylation factor-like 8A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cardiomyocyte LGR6 alleviates ferroptosis in diabetic cardiomyopathy via regulating mitochondrial biogenesis. Zhao M, et al. Metabolism, 2024 Oct. PMID 39038735
  2. Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma. Huang PY, et al. Nat Genet, 2017 Nov. PMID 28945253, Free PMC Article
  3. LGR6 promotes osteogenesis by activating the Wnt/β-catenin signaling pathway. Liu SL, et al. Biochem Biophys Res Commun, 2019 Oct 29. PMID 31500806
  4. Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing. Doherty L, et al. Bone, 2023 Apr. PMID 36708855, Free PMC Article
  5. Mechanical tension mobilizes Lgr6(+) epidermal stem cells to drive skin growth. Xue Y, et al. Sci Adv, 2022 Apr 29. PMID 35476447, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cardiomyocyte LGR6 alleviates ferroptosis in diabetic cardiomyopathy via regulating mitochondrial biogenesis.
    Title: Cardiomyocyte LGR6 alleviates ferroptosis in diabetic cardiomyopathy via regulating mitochondrial biogenesis.
  2. Resolution of post-lung transplant ischemia-reperfusion injury is modulated via Resolvin D1-FPR2 and Maresin 1-LGR6 signaling.
    Title: Resolution of post-lung transplant ischemia-reperfusion injury is modulated via Resolvin D1-FPR2 and Maresin 1-LGR6 signaling.
  3. Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing.
    Title: Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing.
  4. LGR6-dependent conditional inactivation of E-cadherin and p53 leads to invasive skin and mammary carcinomas in mice.
    Title: LGR6-dependent conditional inactivation of E-cadherin and p53 leads to invasive skin and mammary carcinomas in mice.
  5. Mechanical tension mobilizes Lgr6(+) epidermal stem cells to drive skin growth.
    Title: Mechanical tension mobilizes Lgr6(+) epidermal stem cells to drive skin growth.
  6. Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use.
    Title: Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use.
  7. LGR6 has a role in stimulating maresin 1's key proresolving functions of phagocytes
    Title: Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions.
  8. LGR6 is highly expressed in osteoblastic progenitors, and promotes osteogenesis by enhancing beta-catenin stability to strengthen the Wnt signaling pathway.
    Title: LGR6 promotes osteogenesis by activating the Wnt/β-catenin signaling pathway.
  9. Tumorigenesis was inhibited in Pot1b(-/-);p53(+/+) mice due to cellular senescence. Pot1b(-/-);p53(-/-) tumors also exhibited senescence, but proliferated and metastasized with expansion of Lgr6(+) stem cells indicative of senescence-associated secretory phenotype
    Title: Paracrine Interaction of Cancer Stem Cell Populations Is Regulated by the Senescence-Associated Secretory Phenotype (SASP).
  10. Leucine rich repeat containing G protein coupled receptor 6 (Lgr6) mRNA was found to be diminished in skin tumors.
    Title: Lgr6+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bone regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing G-protein coupled receptor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033409.4 → NP_001028581.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform a precursor

    See identical proteins and their annotated locations for NP_001028581.1

    Status: VALIDATED

    Source sequence(s)
    AC117827, AC133097
    Consensus CDS
    CCDS15314.1
    UniProtKB/Swiss-Prot
    B2RUL8, Q3UVD5, Q80UB8, Q8R301
    Related
    ENSMUSP00000035444.8, ENSMUST00000044828.14
    Conserved Domains (5) summary
    smart00013
    Location:34 → 68
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:143 → 392
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:70 → 91
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:92 → 131
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat

  2. NM_001418305.1 → NP_001405234.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC117827, AC133097

  3. NM_001418307.1 → NP_001405236.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC117827, AC133097

  4. NM_001418308.1 → NP_001405237.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC117827
    UniProtKB/TrEMBL
    D3Z6S4

  5. NM_001418309.1 → NP_001405238.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC117827
    UniProtKB/TrEMBL
    D3Z6S4
    Related
    ENSMUSP00000122334.2, ENSMUST00000137968.8

RNA

  1. NR_184714.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117827, AC133097

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134911038..135033112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529714.1 → XP_006529777.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1

    Conserved Domains (4) summary
    smart00013
    Location:34 → 68
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:60 → 411
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:70 → 91
    LRR_RI; leucine-rich repeat [structural motif]
    cd15362
    Location:538 → 814
    7tmA_LGR6; leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs

  2. XM_036165894.1 → XP_036021787.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X2

    Conserved Domains (4) summary
    smart00013
    Location:34 → 68
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:60 → 427
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:70 → 91
    LRR_RI; leucine-rich repeat [structural motif]
    cd15362
    Location:520 → 796
    7tmA_LGR6; leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs

  3. XM_017321280.2 → XP_017176769.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X3

    Conserved Domains (4) summary
    smart00013
    Location:34 → 68
    LRRNT; Leucine rich repeat N-terminal domain
    PLN00113
    Location:60 → 435
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:70 → 91
    LRR_RI; leucine-rich repeat [structural motif]
    cd15362
    Location:562 → 838
    7tmA_LGR6; leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UVD5.1 GenPept UniProtKB/Swiss-Prot:Q3UVD5

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