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Unc80 unc-80, NALCN activator [ Mus musculus (house mouse) ]

Gene ID: 329178, updated on 2-Nov-2024

Summary

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Official Symbol
Unc80provided by MGI
Official Full Name
unc-80, NALCN activatorprovided by MGI
Primary source
MGI:MGI:2652882
See related
Ensembl:ENSMUSG00000055567 AllianceGenome:MGI:2652882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UNC-80; C030018G13Rik; C230061B10Rik
Summary
Predicted to enable monoatomic cation channel activity. Predicted to be involved in monoatomic cation homeostasis. Part of sodium channel complex. Orthologous to human UNC80 (unc-80 homolog, NALCN channel complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 20.7), frontal lobe adult (RPKM 16.0) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Unc80 in Genome Data Viewer
Location:
1 C3; 1 33.56 cM
Exon count:
66
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (66507093..66738309)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (66467915..66699150)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 2 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01187 Neighboring gene STARR-seq mESC enhancer starr_01188 Neighboring gene predicted gene, 25411 Neighboring gene STARR-seq mESC enhancer starr_01189 Neighboring gene predicted gene, 39655 Neighboring gene STARR-seq mESC enhancer starr_01190 Neighboring gene STARR-seq mESC enhancer starr_01191 Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene STARR-positive B cell enhancer ABC_E5767 Neighboring gene ribulose-5-phosphate-3-epimerase Neighboring gene predicted gene, 46093 Neighboring gene heat shock protein 1 (chaperonin) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Imbalance in Unc80 RNA Editing Disrupts Dynamic Neuronal Activity and Olfactory Perception. Chen HW, et al. Int J Mol Sci, 2024 May 30. PMID 38892173, Free PMC Article
  2. Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Lu B, et al. Nature, 2009 Feb 5. PMID 19092807, Free PMC Article
  3. Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex. Wie J, et al. Nat Commun, 2020 Jul 3. PMID 32620897, Free PMC Article
  4. Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Lu B, et al. Neuron, 2010 Nov 4. PMID 21040849, Free PMC Article
  5. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Imbalance in Unc80 RNA Editing Disrupts Dynamic Neuronal Activity and Olfactory Perception.
    Title: Imbalance in Unc80 RNA Editing Disrupts Dynamic Neuronal Activity and Olfactory Perception.
  2. Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.
    Title: Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.
  3. Therefore, extracellular Ca(2+) influences neuronal excitability through the unc-79 homolog modifier of locomotor activity 3-UNC80-NALCN complex in a G protein-dependent fashion
    Title: Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.
  4. in the mouse hippocampal and ventral tegmental area neurons, substance P and neurotensin activate a channel complex containing NALCN and a large previously unknown protein UNC-80
    Title: Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • AC118589.3

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic cation homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of sodium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein unc-80 homolog
Names
NALCN channel associated protein
unc-80 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368824.1 → NP_001355753.1  protein unc-80 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091465, AC118589, AC131577
    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  2. NM_001368825.1 → NP_001355754.1  protein unc-80 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091465, AC118589, AC131577
    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  3. NM_175510.4 → NP_780719.2  protein unc-80 homolog isoform 2

    See identical proteins and their annotated locations for NP_780719.2

    Status: VALIDATED

    Source sequence(s)
    AC091465, AC118589, AC131577
    Consensus CDS
    CCDS48283.1
    UniProtKB/Swiss-Prot
    B2KGE8, B2KGG4, B8XCJ6, Q69Z93, Q8BJN5, Q8BLN6, Q8BLP6
    UniProtKB/TrEMBL
    A0A1D5RLV3
    Related
    ENSMUSP00000053692.10, ENSMUST00000061620.17
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    66507093..66738309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165856.1 → XP_036021749.1  protein unc-80 homolog isoform X19

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  2. XM_036165835.1 → XP_036021728.1  protein unc-80 homolog isoform X8

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  3. XM_036165837.1 → XP_036021730.1  protein unc-80 homolog isoform X10

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  4. XM_036165863.1 → XP_036021756.1  protein unc-80 homolog isoform X21

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  5. XM_036165809.1 → XP_036021702.1  protein unc-80 homolog isoform X1

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  6. XM_036165836.1 → XP_036021729.1  protein unc-80 homolog isoform X9

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  7. XM_036165841.1 → XP_036021734.1  protein unc-80 homolog isoform X12

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  8. XM_036165839.1 → XP_036021732.1  protein unc-80 homolog isoform X11

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  9. XM_036165844.1 → XP_036021737.1  protein unc-80 homolog isoform X13

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  10. XM_006496086.4 → XP_006496149.1  protein unc-80 homolog isoform X5

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  11. XM_036165847.1 → XP_036021740.1  protein unc-80 homolog isoform X14

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  12. XM_036165851.1 → XP_036021744.1  protein unc-80 homolog isoform X17

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  13. XM_036165810.1 → XP_036021703.1  protein unc-80 homolog isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  14. XM_036165824.1 → XP_036021717.1  protein unc-80 homolog isoform X6

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  15. XM_036165849.1 → XP_036021742.1  protein unc-80 homolog isoform X15

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Related
    ENSMUSP00000148517.2, ENSMUST00000212557.3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  16. XM_036165815.1 → XP_036021708.1  protein unc-80 homolog isoform X3

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  17. XM_036165850.1 → XP_036021743.1  protein unc-80 homolog isoform X16

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  18. XM_036165854.1 → XP_036021747.1  protein unc-80 homolog isoform X18

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  19. XM_036165816.1 → XP_036021709.1  protein unc-80 homolog isoform X4

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  20. XM_036165830.1 → XP_036021723.1  protein unc-80 homolog isoform X7

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  21. XM_036165859.1 → XP_036021752.1  protein unc-80 homolog isoform X20

    UniProtKB/TrEMBL
    A0A1D5RLV3
    Conserved Domains (1) summary
    pfam15778
    Location:16 → 236
    UNC80; Cation channel complex component UNC80

  22. XM_036165864.1 → XP_036021757.1  protein unc-80 homolog isoform X22

  23. XM_036165866.1 → XP_036021759.1  protein unc-80 homolog isoform X23

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLN6.3 GenPept UniProtKB/Swiss-Prot:Q8BLN6

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