wgn wengen [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wgnprovided by FlyBase
Official Full Name: wengenprovided by FlyBase
Primary source: FLYBASE:FBgn0030941
Locus tag: Dmel_CG6531
See related: AllianceGenome:FB:FBgn0030941
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6531; Dmel\CG6531; TNFR; vader; Wengen; Wgn; Wng
Summary: Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including negative regulation of neuromuscular synaptic transmission; photoreceptor cell axon guidance; and tumor necrosis factor-mediated signaling pathway. Located in cell surface. Is integral component of plasma membrane. Is expressed in several structures, including embryonic foregut; extended germ band embryo; mesoderm anlage; muscle system; and primary trachea. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18624042..18634908, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18518075..18528941, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Title: Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Wgn-Moe signaling cascade plays a key role in photoreceptor target field innervations through cell autonomous and non-cell autonomous mechanisms.
Title: Wengen, the sole tumour necrosis factor receptor in Drosophila, collaborates with moesin to control photoreceptor axon targeting during development.
roles of wengen
Title: Eiger and wengen: the Drosophila orthologs of TNF/TNFR.
Eiger and Wengen represent proximal components of an evolutionarily conserved TNF-like signaling pathway in Drosophila.
Title: Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila.
results suggest that Wengen can act as a component of a functional receptor for Eiger
Title: Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables tumor necrosis factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuromuscular synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed