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COX2 cytochrome c oxidase subunit II [ Bos taurus (cattle) ]

Gene ID: 3283880, updated on 4-Oct-2024

Summary

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Gene symbol
COX2
Gene description
cytochrome c oxidase subunit II
Locus tag
KEH36_p10
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus (breed: Korean native)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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Genomic context

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See COX2 in Genome Data Viewer
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) MT (non-nuclear) NC_006853.1 (7374..8057)

Chromosome MT - NC_006853.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit I Neighboring gene tRNA-Ser Neighboring gene tRNA-Asp Neighboring gene tRNA-Lys Neighboring gene ATP synthase F0 subunit 8 Neighboring gene ATP synthase F0 subunit 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_006853.1 Chromosome MT Reference ARS-UCD2.0 non-nuclear

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Connecting CuA with metal centers of heme a, heme a(3), CuB and Zn by pathways with hydrogen bond as the bridging element in cytochrome c oxidase. Ramasarma T, et al. Biochem Biophys Res Commun, 2019 Mar 5. PMID 30686530
  2. A theoretical investigation of the functional role of the axial methionine ligand of the Cu(A) site in cytochrome c oxidase. Kang J, et al. Biochim Biophys Acta, 2011 Oct. PMID 21745457
  3. Radical formation in cytochrome c oxidase. Yu MA, et al. Biochim Biophys Acta, 2011 Oct. PMID 21718686, Free PMC Article
  4. The O(2) reduction and proton pumping gate mechanism of bovine heart cytochrome c oxidase. Yoshikawa S, et al. Biochim Biophys Acta, 2011 Oct. PMID 21718684
  5. First-principles molecular dynamics study on the atomistic behavior of His503 in bovine cytochrome c oxidase. Kamiya K, et al. Biochim Biophys Acta, 2011 Oct. PMID 21565155

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cholate Disrupts Regulatory Functions of Cytochrome c Oxidase.
    Title: Cholate Disrupts Regulatory Functions of Cytochrome c Oxidase.
  2. structural analysis of the formation of monomeric CcO, dimeric CcO, and supercomplex, as well as their role in regulation of CcO activity
    Title: Monomeric structure of an active form of bovine cytochrome c oxidase.
  3. analysis of connection of CuA with metal centers of heme a, heme a3, CuB and Zn by pathways with hydrogen bond as the bridging element in cytochrome c oxidase
    Title: Connecting CuA with metal centers of heme a, heme a(3), CuB and Zn by pathways with hydrogen bond as the bridging element in cytochrome c oxidase.
  4. Data show that when the contributions from the reductants are subtracted from the spectra, no evidence for a protein-based radical could be found in the reaction of O(2) with reduced bCcO.
    Title: Radical formation in cytochrome c oxidase.
  5. Data indicate that the proton-pumping pathway of heart cytochrome c oxidase includes a hydrogen-bond network and a water channel located in tandem between the positive and negative side of the mitochondrial membrane.
    Title: The O(2) reduction and proton pumping gate mechanism of bovine heart cytochrome c oxidase.
  6. Study suggests that His503 is involved in the proton supply to the D-path as a proton acceptor in cytochrome c oxidase.
    Title: First-principles molecular dynamics study on the atomistic behavior of His503 in bovine cytochrome c oxidase.
  7. Data suggest that the axial Met residue moderately increased the redox potential of the Cu(A) site in cytochrome c oxidase.
    Title: A theoretical investigation of the functional role of the axial methionine ligand of the Cu(A) site in cytochrome c oxidase.
  8. Studies indicate that heart cytochrome c oxidase subunits I, II and III are encoded by the mitochondrial genome.
    Title: Redox Bohr effects and the role of heme a in the proton pump of bovine heart cytochrome c oxidase.
  9. extensive pre- and intrapartal rise of COX-II expression in bovine placentomes with a 70-100-fold increase of COX-II-mRNA levels
    Title: Expression of cyclooxygenase-II (COX-II) and 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD)/prostaglandin F-synthase (PGFS) in bovine placentomes: implications for the initiation of parturition in cattle.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

General protein information

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Preferred Names
cytochrome c oxidase subunit II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006853.1 Reference assembly

    Range
    7374..8057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_209208.1 cytochrome c oxidase subunit II (mitochondrion) [Bos taurus]

    See identical proteins and their annotated locations for YP_209208.1

    Status: VALIDATED

    UniProtKB/Swiss-Prot
    P68530
    UniProtKB/TrEMBL
    B1P072, Q3L5W1, Q6QTG8, Q7JAT3, Q8M444
    Conserved Domains (1) summary
    MTH00098
    Location:1 → 227
    COX2; cytochrome c oxidase subunit II; Validated
Nucleotide Protein
Heading Accession and Version

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