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CrebB Cyclic-AMP response element binding protein B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32817, updated on 2-Nov-2024

Summary

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Official Symbol
CrebBprovided by FlyBase
Official Full Name
Cyclic-AMP response element binding protein Bprovided by FlyBase
Primary source
FLYBASE:FBgn0265784
Locus tag
Dmel_CG6103
See related
AllianceGenome:FB:FBgn0265784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6103; CRE-BP; Creb; CREB; Creb B 17A; Creb-B; CREB-b; CREB-B; Creb17A; creb2; Creb2; CREB2; Creb2-b; CREB2-b; Creb2.b; CREB2a; Creb2b; CREB2b; crebB; CrebB-17A; CrebB-17B; CrebB17-A; dCbz; dCREB; dCREB-2; dCREB-2a; dCREB-B; dCreb2; dCREB2; dCREB2-a; dcreb2-b; dCreb2-b; dCREB2-b; dCREB2a; dCreb2b; dCREB2b; dCrebB2; DM9; Dmel\CG6103; FBgn0014467; l(1)17Af; S162
Summary
Enables sequence-specific DNA binding activity. Involved in several processes, including memory; positive regulation of feeding behavior; and thermosensory behavior. Located in nucleus. Is expressed in adult head and organism. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Orthologous to human ATF1 (activating transcription factor 1); CREB1 (cAMP responsive element binding protein 1); and CREM (cAMP responsive element modulator). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CrebB in Genome Data Viewer
Location:
17A7-17A8; 1-60 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18366357..18377864)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18260390..18271897)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene kairos Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43686 Neighboring gene porcupine Neighboring gene uncharacterized protein Neighboring gene Coat Protein (coatomer) beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gut microbiota metabolite tyramine ameliorates high-fat diet-induced insulin resistance via increased Ca(2+) signaling. Ma P, et al. EMBO J, 2024 Aug. PMID 38965418, Free PMC Article
  2. dCREB2-mediated enhancement of memory formation. Tubon TC Jr, et al. J Neurosci, 2013 Apr 24. PMID 23616553, Free PMC Article
  3. Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila. Lee WP, et al. PLoS Genet, 2020 Aug. PMID 32780743, Free PMC Article
  4. Time of day influences memory formation and dCREB2 proteins in Drosophila. Fropf R, et al. Front Syst Neurosci, 2014. PMID 24744705, Free PMC Article
  5. A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. Yin JC, et al. Mol Cell Biol, 1995 Sep. PMID 7651429, Free PMC Article

See all (239) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila.
    Title: CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila.
  2. Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila.
    Title: Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila.
  3. pharmaceutical inhibition of CDK5 prevents glioma stem cell self-renewal in vitro and in xenografted tumors, at least partially by suppressing CREB1 activation independently of PKA/cAMP.
    Title: CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells.
  4. c-Fos/CREB cycling defines long-term memories (LTM) engram cells required for LTM.
    Title: Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling.
  5. Data demonstrate that CrebB is a rate-limiting substrate of the genetic NMD pathway important for the behavioral output of circadian clocks in Drosophila.
    Title: Drosophila CrebB is a Substrate of the Nonsense-Mediated mRNA Decay Pathway that Sustains Circadian Behaviors.
  6. The authors show that PKA phosphorylates Meng Po and that both proteins synergize in a feedforward loop to control CREBB levels and long-term memory.
    Title: A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.
  7. Mushroom Body alpha/beta and alpha'/beta' neurons as well as MBON alpha3, but not in dopaminergic neurons require CrebB for long term memory.
    Title: Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit.
  8. Early-onset sleep defects in mutated HTT Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.
    Title: Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.
  9. changes suggest that dCREB2 functions in both the ellipsoid body and the mushroom body for long term memory formation, and that this activity contributes to the process of systems consolidation.
    Title: Spatio-temporal in vivo recording of dCREB2 dynamics in Drosophila long-term memory processing.
  10. Our data suggest the model that Notch and PKC activities generate a cyclical accumulation of cytoplasmic hyper-PO4 CREB that is a precursor for generating the nuclear CREB isoforms.
    Title: Notch-inducible hyperphosphorylated CREB and its ultradian oscillation in long-term memory formation.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in anesthesia-resistant memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian rhythm TAS
Traceable Author Statement
more info
 PubMed 
NOT involved_in learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in learning or memory NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in locomotor rhythm NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in long-term memory IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-term memory IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term memory TAS
Traceable Author Statement
more info
 PubMed 
involved_in medium-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of feeding behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of circadian sleep/wake cycle, sleep TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rhythmic behavior TAS
Traceable Author Statement
more info
 PubMed 
involved_in sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thermosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Cyclic-AMP response element binding protein B
Names
CG6103-PF
CG6103-PG
CG6103-PI
CG6103-PJ
CG6103-PM
CG6103-PN
CG6103-PO
CG6103-PP
CG6103-PQ
CG6103-PR
CREB
CrebB-PF
CrebB-PG
CrebB-PI
CrebB-PJ
CrebB-PM
CrebB-PN
CrebB-PO
CrebB-PP
CrebB-PQ
CrebB-PR
Cyclic-AMP response element binding protein B at 17A
Cyclic-AMP response element binding protein B at 17B
activator
blocker
cAMP response element binding
cAMP response element-binding protein
cAMP response-element binding protein
cAMP-regulated enhancer-binding protein
cAMP-response element binding protein
cAMP-response element-binding protein
cyclic AMP response element binding protein
dCREB2
lethal(1)17Af
protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18366357..18377864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103546.3 → NP_001097016.2  Cyclic-AMP response element binding protein B, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097016.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHW9
    Conserved Domains (2) summary
    cd14690
    Location:224 → 277
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:187 → 210
    pKID; pKID domain

  2. NM_001103547.4 → NP_001097017.1  Cyclic-AMP response element binding protein B, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097017.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHZ6
    Conserved Domains (2) summary
    cd14690
    Location:270 → 323
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:187 → 210
    pKID; pKID domain

  3. NM_001103548.4 → NP_001097018.1  Cyclic-AMP response element binding protein B, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097018.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHW9
    Conserved Domains (2) summary
    cd14690
    Location:224 → 277
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:187 → 210
    pKID; pKID domain

  4. NM_001272749.2 → NP_001259678.1  Cyclic-AMP response element binding protein B, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259678.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHW9
    Conserved Domains (2) summary
    cd14690
    Location:224 → 277
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:187 → 210
    pKID; pKID domain

  5. NM_001382186.1 → NP_001368947.1  Cyclic-AMP response element binding protein B, isoform R [Drosophila melanogaster]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd14690
    Location:139 → 192
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:56 → 79
    pKID; pKID domain

  6. NM_001347813.2 → NP_001334685.1  Cyclic-AMP response element binding protein B, isoform Q [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1Z1CK36

  7. NM_001272748.3 → NP_001259677.1  Cyclic-AMP response element binding protein B, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259677.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHZ6
    Conserved Domains (2) summary
    cd14690
    Location:270 → 323
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:187 → 210
    pKID; pKID domain

  8. NM_001258811.3 → NP_001245740.1  Cyclic-AMP response element binding protein B, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245740.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SUU1
    Conserved Domains (1) summary
    pfam02173
    Location:191 → 220
    pKID; pKID domain

  9. NM_206781.4 → NP_996504.1  Cyclic-AMP response element binding protein B, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996504.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VWW0
    Conserved Domains (2) summary
    cd14690
    Location:228 → 281
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:191 → 214
    pKID; pKID domain

  10. NM_206783.4 → NP_996506.2  Cyclic-AMP response element binding protein B, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996506.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHZ6
    Conserved Domains (2) summary
    cd14690
    Location:270 → 323
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:187 → 210
    pKID; pKID domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1Z1CK36 A0A1Z1CK36
C6SUU1 C6SUU1
M9PHW9 M9PHW9
M9PHZ6 M9PHZ6
Q9VWW0.1 Q9VWW0

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