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ari-1 ariadne 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32796, updated on 18-Sep-2024

Summary

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Official Symbol
ari-1provided by FlyBase
Official Full Name
ariadne 1provided by FlyBase
Primary source
FLYBASE:FBgn0017418
Locus tag
Dmel_CG5659
See related
AllianceGenome:FB:FBgn0017418
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAS65398.1; ari; Ari-1; ari-1a; ARI1_DROME; CG5659; Dmel\CG5659; HL-V; l(1)16Fj
Summary
Enables ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in several processes, including cellular protein metabolic process; positive regulation of neurogenesis; and positive regulation of proteasomal protein catabolic process. Located in cytosol and nucleus. Is expressed in several structures, including adult central nervous system; embryonic/larval muscle system; and gonad. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ari-1 in Genome Data Viewer
Location:
16F7-16F7; 1-59 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18130392..18137784, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18024425..18031817, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mir-210 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Frequenin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF. Ramírez J, et al. J Biol Chem, 2021 Jan-Jun. PMID 33581113, Free PMC Article
  2. High efficiency of a double-screening method on single P-element insertion lines to identify quantitative trait mutants in Drosophila melanogaster. Martin F, et al. Genetica, 2006 Sep-Nov. PMID 17028964
  3. Frequenin/NCS-1 and the Ca2+-channel alpha1-subunit co-regulate synaptic transmission and nerve-terminal growth. Dason JS, et al. J Cell Sci, 2009 Nov 15. PMID 19861494
  4. The ring between ring fingers (RBR) protein family. Eisenhaber B, et al. Genome Biol, 2007. PMID 17367545, Free PMC Article
  5. Recent Developments in Using Drosophila as a Model for Human Genetic Disease. Oriel C, et al. Int J Mol Sci, 2018 Jul 13. PMID 30011838, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF.
    Title: The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF.
  2. Variants in ARI-1 are associated with nuclear clustering and morphology defects in larval muscles and thus developing aortic aneurysms.
    Title: Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms.
  3. Ariadne-1a binds specifically the isoform A of EcR and ubiquitylates it
    Title: Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c18132003-18131319 mobile_element_type = transposon:1360{}154

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein monoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ariadne 1
Names
Ariadne-1
CG5659-PA
CG5659-PB
CG5659-PC
CG5659-PD
CG5659-PE
CG5659-PF
ari-1-PA
ari-1-PB
ari-1-PC
ari-1-PD
ari-1-PE
ari-1-PF
ariadne

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18130392..18137784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258807.3 → NP_001245736.1  ariadne 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245736.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHQ9, Q94981
    UniProtKB/TrEMBL
    A4V4Q7
    Conserved Domains (2) summary
    smart00647
    Location:204 → 264
    IBR; In Between Ring fingers
    pfam01485
    Location:286 → 326
    IBR; IBR domain, a half RING-finger domain

  2. NM_001272742.2 → NP_001259671.1  ariadne 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259671.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHQ9, Q94981
    UniProtKB/TrEMBL
    A4V4Q7
    Conserved Domains (2) summary
    smart00647
    Location:204 → 264
    IBR; In Between Ring fingers
    pfam01485
    Location:286 → 326
    IBR; IBR domain, a half RING-finger domain

  3. NM_001272743.1 → NP_001259672.1  ariadne 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259672.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHQ9, Q94981
    UniProtKB/TrEMBL
    A4V4Q7
    Conserved Domains (2) summary
    smart00647
    Location:204 → 264
    IBR; In Between Ring fingers
    pfam01485
    Location:286 → 326
    IBR; IBR domain, a half RING-finger domain

  4. NM_078675.4 → NP_523399.1  ariadne 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523399.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHQ9, Q94981
    UniProtKB/TrEMBL
    A4V4Q7
    Related
    FBpp0088499
    Conserved Domains (2) summary
    smart00647
    Location:204 → 264
    IBR; In Between Ring fingers
    pfam01485
    Location:286 → 326
    IBR; IBR domain, a half RING-finger domain

  5. NM_206777.2 → NP_996500.1  ariadne 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996500.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHQ9, Q94981
    UniProtKB/TrEMBL
    A4V4Q7
    Conserved Domains (2) summary
    smart00647
    Location:204 → 264
    IBR; In Between Ring fingers
    pfam01485
    Location:286 → 326
    IBR; IBR domain, a half RING-finger domain

  6. NM_167610.4 → NP_728145.1  ariadne 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728145.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KHQ9, Q94981
    UniProtKB/TrEMBL
    A4V4Q7
    Related
    FBpp0088500
    Conserved Domains (2) summary
    smart00647
    Location:204 → 264
    IBR; In Between Ring fingers
    pfam01485
    Location:286 → 326
    IBR; IBR domain, a half RING-finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V4Q7 A4V4Q7
Q86NL7 Q86NL7
Q94981.2 Q94981

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