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Ccn6 cellular communication network factor 6 [ Mus musculus (house mouse) ]

Gene ID: 327743, updated on 2-Nov-2024

Summary

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Official Symbol
Ccn6provided by MGI
Official Full Name
cellular communication network factor 6provided by MGI
Primary source
MGI:MGI:2685581
See related
Ensembl:ENSMUSG00000062074 AllianceGenome:MGI:2685581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm735; Wisp3; WISP-3
Summary
Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in several processes, including positive regulation of cell differentiation; regulation of mitochondrial membrane potential; and regulation of reactive oxygen species biosynthetic process. Predicted to act upstream of or within negative regulation of angiogenesis and negative regulation of cell population proliferation. Predicted to be located in mitochondrion. Predicted to be active in extracellular matrix and extracellular space. Is expressed in embryo. Used to study breast metaplastic carcinoma and progressive pseudorheumatoid arthropathy of childhood. Human ortholog(s) of this gene implicated in arthropathy and progressive pseudorheumatoid arthropathy of childhood. Orthologous to human CCN6 (cellular communication network factor 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thymus adult (RPKM 11.6), CNS E11.5 (RPKM 4.9) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Ccn6 in Genome Data Viewer
Location:
10 B1; 10 20.19 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39026966..39049484, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39150970..39174376, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene laminin, alpha 4 Neighboring gene STARR-seq mESC enhancer starr_26379 Neighboring gene STARR-seq mESC enhancer starr_26383 Neighboring gene family with sequence similarity 229, member B Neighboring gene STARR-seq mESC enhancer starr_26384 Neighboring gene tubulin, epsilon 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:38891010-38891195 Neighboring gene STARR-positive B cell enhancer ABC_E3883 Neighboring gene STARR-positive B cell enhancer ABC_E1797 Neighboring gene STARR-seq mESC enhancer starr_26386 Neighboring gene STARR-seq mESC enhancer starr_26387 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene, 31562

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas. Martin EE, et al. Oncogene, 2017 Apr 20. PMID 27819674, Free PMC Article
  2. Aurora A Kinase (AURKA) is required for male germline maintenance and regulates sperm motility in the mouse. Lester WC, et al. Biol Reprod, 2021 Dec 20. PMID 34518881, Free PMC Article
  3. WISP-3/CCN6 inhibits apoptosis by regulating caspase pathway after hyperoxia in lung epithelial cells. Wei S, et al. Gene, 2018 Oct 5. PMID 29920361
  4. A Wisp3 Cre-knockin allele produces efficient recombination in spermatocytes during early prophase of meiosis I. Hann S, et al. PLoS One, 2013. PMID 24040393, Free PMC Article
  5. WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice. Kutz WE, et al. Mol Cell Biol, 2005 Jan. PMID 15601861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WISP-3/CCN6 has a role in inhibiting apoptosis by regulating caspase pathway after hyperoxia in lung epithelial cells
    Title: WISP-3/CCN6 inhibits apoptosis by regulating caspase pathway after hyperoxia in lung epithelial cells.
  2. demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin beta1, leading to the phosphorylation of FAK(Y397).
    Title: CCN6 as a profibrotic mediator that stimulates the proliferation of lung fibroblasts via the integrin β1/focal adhesion kinase pathway.
  3. the WISP3 gene is essential to skeletal growth or homeostasis in humans but not in mice [WISP3]
    Title: WISP3, the gene responsible for the human skeletal disease progressive pseudorheumatoid dysplasia, is not essential for skeletal function in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of reactive oxygen species biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cellular communication network factor 6
Names
CCN family member 6
WNT1 inducible signaling pathway protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127376.1 → NP_001120848.1  cellular communication network factor 6 precursor

    See identical proteins and their annotated locations for NP_001120848.1

    Status: VALIDATED

    Source sequence(s)
    AC153958
    Consensus CDS
    CCDS48537.1
    UniProtKB/Swiss-Prot
    D3Z5L9
    Related
    ENSMUSP00000076003.5, ENSMUST00000076713.6
    Conserved Domains (3) summary
    pfam00219
    Location:48 → 100
    IGFBP; Insulin-like growth factor binding protein
    pfam19035
    Location:209 → 252
    TSP1_CCN; CCN3 Nov like TSP1 domain
    cl21545
    Location:275 → 341
    GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    39026966..39049484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155821.1 → XP_036011714.1  cellular communication network factor 6 isoform X1

    UniProtKB/Swiss-Prot
    D3Z5L9
    Conserved Domains (3) summary
    pfam00219
    Location:48 → 100
    IGFBP; Insulin-like growth factor binding protein
    pfam19035
    Location:209 → 252
    TSP1_CCN; CCN3 Nov like TSP1 domain
    cl21545
    Location:275 → 341
    GHB_like; Glycoprotein hormone beta chain homologues

  2. XM_030245127.2 → XP_030100987.1  cellular communication network factor 6 isoform X1

    UniProtKB/Swiss-Prot
    D3Z5L9
    Conserved Domains (3) summary
    pfam00219
    Location:48 → 100
    IGFBP; Insulin-like growth factor binding protein
    pfam19035
    Location:209 → 252
    TSP1_CCN; CCN3 Nov like TSP1 domain
    cl21545
    Location:275 → 341
    GHB_like; Glycoprotein hormone beta chain homologues

  3. XM_036155822.1 → XP_036011715.1  cellular communication network factor 6 isoform X1

    UniProtKB/Swiss-Prot
    D3Z5L9
    Conserved Domains (3) summary
    pfam00219
    Location:48 → 100
    IGFBP; Insulin-like growth factor binding protein
    pfam19035
    Location:209 → 252
    TSP1_CCN; CCN3 Nov like TSP1 domain
    cl21545
    Location:275 → 341
    GHB_like; Glycoprotein hormone beta chain homologues
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3Z5L9.2 GenPept UniProtKB/Swiss-Prot:D3Z5L9

Gene LinkOut

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